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• Coverpage
• Halftitle page
• CAMBRIDGE TEXTS IN BIOMEDICAL ENGINEERING
• Title page
• Copyright page
• Contents
• Symbols
• Prologue
• Part I Materials
• 1 Biocompatibility, sterilization, and materials selection for implant design
• 1.1 Historical perspective and overview
• 1.2 Learning objectives
• 1.3 Successful device performance and implant design
• 1.4 Biocompatibility
• 1.5 Sterility
• 1.6 Regulatory issues
• 1.7 Structural requirements
• 1.8 Classifying biomaterials
• 1.9 Structure-property relationships
• 1.10 Attributes and limitations of synthetic biomaterials
• 1.11 Case study: deterioration of orthopedic-grade UHMWPE due to ionizing radiation
• 1.12 Summary
• 1.13 Problems for consideration
• 1.14 References
• 2 Metals for medical implants
• 2.1 Historical perspective and overview
• 2.2 Learning objectives
• 2.3 Bonding and crystal structure
• 2.4 Interstitial sites
• 2.5 Crystallographic planes and directions
• 2.6 Theoretical shear strength
• 2.7 Imperfections in metals and alloys
• 2.8 Metal processing
• 2.9 Corrosion processes
• 2.10 Metals in medical implants
• 2.11 Case study: corrosion in modular orthopedic implants
• 2.12 Summary
• 2.13 Problems for consideration
• 2.14 References
• 3 Ceramics
• 3.1 Historical perspective and overview
• 3.2 Learning objectives
• 3.3 Bonding and crystal structure
• 3.4 Mechanical behavior of ceramics
• 3.5 Processing of ceramics
• 3.6 Ceramics in medical implants
• 3.7 Case study: the use of coral as a bone substitute
• 3.8 Summary
• 3.9 Problems for consideration
• 3.10 References
• 4 Polymers
• 4.1 Historical perspective and overview
• 4.2 Learning objectives
• 4.3 Bonding and crystal structure
• 4.4 Molecular weight distribution in polymers
• 4.5 Mechanical behavior of polymers
• 4.6 Polymer processing
• 4.7 Polymers in medical implants
• 4.8 Case study: resorbable sutures and suture anchors
• 4.9 Summary
• 4.10 Problems for consideration
• 4.11 References
• 5 Mechanical behavior of structural tissues
• 5.1 Historical perspective and overview
• 5.2 Learning objectives
• 5.3 Building blocks of tissues
• 5.4 Load-bearing tissues
• 5.5 Case study: creating a scaffold for tissue engineering
• 5.6 Summary
• 5.7 Problems for consideration
• 5.8 References
• 5.9 Bibliography
• Part II Mechanics
• 6 Elasticity
• 6.1 Overview
• 6.2 Learning objectives
• 6.3 Stress and strain
• 6.4 Bending stresses and beam theory
• 6.5 Composites
• 6.6 Case study: modifying material and cross-section to reduce bone absorption
• 6.7 Summary
• 6.8 Problems for consideration
• 6.9 References
• 6.10 Bibliography
• 7 Viscoelasticity
• 7.1 Overview
• 7.2 Learning objectives
• 7.3 Introduction to viscoelasticity
• 7.4 Linear viscoelastic networks
• 7.5 Frequency domain analysis
• 7.6 Time-temperature equivalence
• 7.7 Nonlinear viscoelasticity
• 7.8 Case study: creep behavior of UHMWPE used in total joint replacements
• 7.9 Summary
• 7.10 Problems for consideration
• 7.11 References
• 8 Failure theories
• 8.1 Overview
• 8.2 Learning objectives
• 8.3 Yield surfaces
• 8.4 Maximum shear stress (Tresca yield criterion)
• 8.5 Maximum distortional energy (von Mises yield criterion)
• 8.6 Predicting yield in multiaxial loading conditions
• 8.7 Modified yield criteria
• 8.8 Maximum normal stress failure theory
• 8.9 Notches and stress concentrations
• 8.10 Failure mechanisms in structural biomaterials
• 8.11 Case study: stress distribution in a total joint replacement
• 8.12 Summary
• 8.13 Problems for consideration
• 8.14 References
• 9 Fracture mechanics
• 9.1 Overview
• 9.2 Learning objectives
• 9.3 Linear elastic fracture mechanics (LEFM)
• 9.4 Modified methods in LEFM
• 9.5 Elastic-plastic fracture mechanics (EPFM)
• 9.6 Time-dependent fracture mechanics (TDFM)
• 9.7 Intrinsic and extrinsic fracture processes
• 9.8 Fracture mechanisms in structural materials
• 9.9 Case study: fracture of highly crosslinked acetabular liners
• 9.10 Summary
• 9.11 Problems for consideration
• 9.12 References
• 10 Fatigue
• 10.1 Overview
• 10.2 Learning objectives
• 10.3 Fatigue terminology
• 10.4 Total life philosophy
• 10.5 Strain-based loading
• 10.6 Marin factors
• 10.7 Defect-tolerant philosophy
• 10.8 Case study: fatigue fractures in trapezoidal hip stems
• 10.9 Summary
• 10.10 Problems for consideration
• 10.11 References
• 11 Friction, lubrication, and wear
• 11.1 Overview
• 11.2 Learning objectives
• 11.3 Bulk and surface properties
• 11.4 Friction
• 11.5 Surface contact mechanics
• 11.6 Lubrication
• 11.7 Wear
• 11.8 Surface contact in biomaterials
• 11.9 Friction and wear test methods
• 11.10 Design factors
• 11.11 Case study: the use of composites in total joint replacements
• 11.12 Summary
• 11.13 Problems for consideration
• 11.14 References
• Part III Case studies
• 12 Regulatory affairs and testing
• 12.1 Historical perspective and overview
• 12.2 Learning objectives
• 12.3 FDA legislative history
• 12.4 Medical device definitions and classifications
• 12.5 CDRH organization
• 12.6 Anatomy of a testing standard
• 12.7 Development of testing standards
• 12.8 International regulatory bodies
• 12.9 Case study: examining a 510(k) approval
• 12.10 Summary
• 12.11 Problems for consideration
• 12.12 References
• 13 Orthopedics
• 13.1 Historical perspective and overview
• 13.2 Learning objectives
• 13.3 Total joint replacements
• 13.4 Total hip arthroplasty
• 13.5 Total knee arthroplasty
• 13.6 Fracture fixation
• 13.7 Spinal implants
• 13.8 Engineering challenges and design constraints of orthopedic implants
• 13.9 Case studies
• 13.10 Summary
• 13.11 Looking forward in orthopedic implants
• 13.12 Problems for consideration
• 13.13 References
• 14 Cardiovascular devices
• 14.1 Historical perspective and overview
• 14.2 Learning objectives
• 14.3 Cardiovascular anatomy
• 14.4 Load-bearing devices
• 14.5 Case studies
• 14.6 Looking forward
• 14.7 Summary
• 14.8 Problems for consideration
• 14.9 References
• 15 Oral and maxillofacial devices
• 15.1 Overview
• 15.2 Learning objectives
• 15.3 Oral and maxillofacial anatomy
• 15.4 Dental implants
• 15.5 Temporomandibular joint replacements
• 15.6 Case studies
• 15.7 Looking forward
• 15.8 Summary
• 15.9 Problems for consideration
• 15.10 References
• 16 Soft tissue replacements
• 16.1 Historical perspective and overview
• 16.2 Learning objectives
• 16.3 Sutures
• 16.4 Synthetic ligament
• 16.5 Artificial skin
• 16.6 Ophthalmic implants
• 16.7 Cosmetic implants
• 16.8 Case studies
• 16.9 Looking forward
• 16.10 Summary
• 16.11 Problems for consideration
• 16.12 References
• Epilogue
• Appendix A. Selected topics from mechanics of materials
• Appendix B. Table of material properties of engineering biomaterials and tissues
• Appendix C. Teaching methodologies in biomaterials
• Glossary
• Index