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• Cover
• Half Title
• Publisher’s Notice
• Title Page
• Copyright
• Preface
• Note to the Reader
• Nomenclature for Genes and Proteins
• Resources for Instructors
• About the Authors
• Acknowledgments
• Brief Contents
• Special Features
• Contents
• Part I: Introduction to the Cell
• Chapter 1: Cells, Genomes, and the Diversity of Life
• The Universal Features of Life on Earth
• Genome Diversification and the Tree of Life
• Eukaryotes and the Origin of the Eukaryotic Cell
• Model Organisms
• Problems
• References
• Chapter 2: Cell Chemistry and Bioenergetics
• The Chemical Components of a Cell
• Catalysis and the Use of Energy By Cells
• How Cells Obtain Energy From Food
• Problems
• References
• Chapter 3: Proteins
• The Atomic Structure of Proteins
• Protein Function
• Problems
• References
• Part II: Basic Genetic Mechanisms
• Chapter 4: DNA, Chromosomes, and Genomes
• The Structure and Function of DNA
• Chromosomal DNA and its Packaging in the Chromatin Fiber
• The Effect of Chromatin Structure on DNA Function
• The Global Structure of Chromosomes
• How Genomes Evolve
• Problems
• References
• Chapter 5: DNA Replication, Repair, and Recombination
• The Maintenance of DNA Sequences
• DNA Replication Mechanisms
• The Initiation and Completion of DNA Replication in Chromosomes
• DNA Repair
• Homologous Recombination
• Transposition and Conservative Site-Specific Recombination
• Problems
• References
• Chapter 6: How Cells Read the Genome: From DNA to Protein
• From DNA to RNA
• From RNA to Protein
• The RNA World and the Origins of Life
• Problems
• References
• Chapter 7: Control of Gene Expression
• An Overview of Gene Control
• Control of Transcription by Sequence-Specific DNA-Binding Proteins
• Transcription Regulators Switch Genes on and Off
• Molecular Genetic Mechanisms That Create and Maintain Specialized Cell Types
• Mechanisms That Reinforce Cell Memory in Plants and Animals
• Post-Transcriptional Controls
• Regulation of Gene Expression by Noncoding Rnas
• Problems
• References
• Part III: Ways of Working With Cells
• Chapter 8: Analyzing Cells, Molecules, and Systems
• Isolating Cells and Growing Them in Culture
• Purifying Proteins
• Analyzing-Proteins
• Analyzing and Manipulating DNA
• Studying Gene Function and Expression
• Mathematical Analysis of Cell Function
• Problems
• References
• Chapter 9: Visualizing Cells and Their Molecules
• Looking at Cells and Molecules in the Light Microscope
• Looking at Cells and Molecules in the Electron Microscope
• Problems
• References
• Part IV: Internal Organization of the Cell
• Chapter 10: Membrane Structure
• The Lipid Bilayer
• Membrane Proteins
• Problems
• References
• Chapter 11: Small-Molecule Transport and Electrical Properties of Membranes
• Principles of Membrane Transport
• Transporters and Active Membrane Transport
• Channels and the Electrical Properties of Membranes
• Problems
• References
• Chapter 12: Intracellular Organization and Protein Sorting
• The Compartmentalization Of Cells
• The Endoplasmic Reticulum
• Peroxisomes
• The Transport of Proteins into Mitochondria and Chloroplasts
• The Transport of Molecules Between the Nucleus and the Cytosol
• Problems
• References
• Chapter 13: Intracellular Membrane Traffic
• Mechanisms of Membrane Transport and Compartment Identity
• Transport from the Endoplasmic Reticulum Through the Golgi Apparatus
• Transport From the Trans Golgi Network to the Cell Exterior and Endosomes
• Transport into the Cell from the Plasma Membrane: Endocytosis
• The Degradation and Recycling of Macromolecules in Lysosomes
• Problems
• References
• Chapter 14: Energy Conversion and Metabolic Compartmentation: Mitochondria and Chloroplasts
• The Mitochondrion
• The Proton Pumps of the Electron-Transport Chain
• ATP Production in Mitochondria
• Chloroplasts and Photosynthesis
• The Genetic Systems of Mitochondria and Chloroplasts
• Problems
• References
• Chapter 15: Cell Signaling
• Principles of Cell Signaling
• Signaling Through G-Protein-Coupled Receptors
• Signaling Through Enzyme-Coupled Receptors
• Alternative Signaling Routes in Gene Regulation
• Signaling in Plants
• Problems
• References
• Chapter 16: The Cytoskeleton
• Function and Dynamics of the Cytoskeleton
• Actin
• Myosin and Actin
• Microtubules
• Intermediate Filaments and Other Cytoskeletal Polymers
• Cell Polarity and Coordination of the Cytoskeleton
• Problems
• References
• Chapter 17: The Cell Cycle
• Overview of the Cell Cycle
• The Cell-Cycle Control System
• S Phase
• Mitosis
• Cytokinesis
• Meiosis
• Control of Cell Division and Cell Growth
• Problems
• References
• Chapter 18: Cell Death
• Problems
• References
• Part V: Cells in Their Social Context
• Chapter 19: Cell Junctions and the Extracellular Matrix
• Cell-Cell Junctions
• The Extracellular Matrix of Animals
• Cell-Matrix Junctions
• The Plant Cell Wall
• Problems
• References
• Chapter 20: Cancer
• Cancer as a Microevolutionary Process
• Cancer-Critical Genes: How They are Found and What They Do
• Cancer Prevention and Treatment: Present and Future
• Problems
• References
• Chapter 21: Development of Multicellular Organisms
• Overview of Development
• Mechanisms of Pattern Formation
• Developmental Timing
• Morphogenesis
• Growth
• Problems
• References
• Chapter 22: Stem Cells in Tissue Homeostasis and Regeneration
• Stem Cells and Tissue Homeostasis
• Control of Stem-Cell Fate and Self-Renewal
• Regeneration and Repair
• Cell Reprogramming and Pluripotent Stem Cells
• Problems
• References
• Chapter 23: Pathogens and Infection
• Introduction to Pathogens
• Cell Biology of Pathogen Infection
• The Human Microbiota
• Problems
• References
• Chapter 24: The Innate and Adaptive Immune Systems
• The Innate Immune System
• Overview of the Adaptive Immune System
• B Cells and Immunoglobulins
• T Cells and MHC Proteins
• Problems
• References
• Glossary
• Index
• About the Covers