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• Cover
• Acknowledgments
• How to Use This Book
• About the Companion Website
• Lecture 1 An Overview
• Introduction
• Physical Barriers
• The Innate Immune System
• The Adaptive Immune System
• A Comparison of the Innate and Adaptive Immune Systems
• The Innate System Rules!
• Epilogue
• Lecture 2 The Innate Immune System
• Introduction
• The Complement System
• The Professional Phagocytes
• How Immune System Sentinels Recognize Invaders
• How the Innate Immune System Deals with Viruses
• The Innate Immune System a Cooperative Effort
• A Proportional Response
• Summary Figure
• Lecture 3 B Cells and Antibodies
• Introduction
• The B Cell Receptor
• How the BCR Signals
• How B Cells are Activated
• Class Switching
• Antibody Classes and their Functions
• Somatic Hypermutation
• B Cells Make a Career Choice
• Summary Figure
• Lecture 4 The Magic of Antigen Presentation
• Introduction
• Class I MHC Molecules
• Class II MHC Molecules
• Antigen Presentation by Class I MHC Molecules
• Antigen Presentation by Class II MHC Molecules
• Antigen Presenting Cells
• The Logic of Class I MHC Presentation
• The Logic of Class II MHC Presentation
• Cross-Presentation
• Non-Classical MHC Molecules and Lipid Presentation
• MHC Proteins and Organ Transplants
• Summary Figure
• Lecture 5 T Cell Activation
• Introduction
• T Cell Receptors
• How a T Cell’s Receptors Signal
• CD4 and CD8 Co-Receptors
• Co-Stimulation
• A Time-Lapse Photo of Helper T Cell Activation
• How Killer T Cells are Activated
• Fail-Safe Activation
• Lecture 6 T Cells at Work
• Introduction
• Helper T Cells as Cytokine Factories
• The Dendritic Cell as “Coach” of the Immune System Team
• Th1 Helper T Cells
• Th2 Helper T Cells
• Th17 Helper T Cells
• Th0 Helper T Cells
• Locking in the Helper T Cell Profile
• Delayed-Type Hypersensitivity
• How CTLs Kill
• Summary Figure
• Lecture 7 Secondary Lymphoid Organs and Lymphocyte Trafficking
• Introduction
• Lymphoid Follicles
• High Endothelial Venules
• Lymph Nodes
• Peyer’s Patches
• The Spleen
• The Logic of Secondary Lymphoid Organs
• Lymphocyte Trafficking
• Why Mothers Kiss Their Babies
• Lecture 8 Restraining the Immune System
• Introduction
• Attenuating the Immune Response
• Deactivating the System
• Life is Short
• Exhaustion
• Lecture 9 Self Tolerance and MHC Restriction
• Introduction
• The Thymus
• MHC Restriction
• The Logic of MHC Restriction
• Thymic Testing for Tolerance of Self
• Graduation
• The Riddle of MHC Restriction and Tolerance Induction
• Tolerance by Ignorance
• Tolerance Induction in Secondary Lymphoid Organs
• Peripheral Tolerance Induction
• Tolerance Due to Activation-Induced Cell Death
• B Cell Tolerance
• Maintenance of B Cell Tolerance in Germinal Centers
• Positive Selection of Natural Killer Cells
• Lecture 10 Immunological Memory
• Introduction
• Innate Memory
• Adaptive Memory
• Properties of Adaptive Memory Cells
• Comparing B and T Cell Memories
• Innate Versus Adaptive Memory
• Lecture 11 The Intestinal Immune System
• Introduction
• Intestinal Architecture
• Challenges Faced by the Intestinal Immune System
• Responding Gently to Limited Threats
• The Intestinal Immune System’s Response to Pathogens
• How to Respond?
• Lecture 12 The Immune System Gone Wrong
• Introduction
• Diseases Caused by Defects in Immune Regulation
• Autoimmune Disease
• Lecture 13 Immunodeficiency
• Introduction
• Genetic Defects Leading to Immunodeficiency
• AIDS
• Lecture 14 Vaccines
• Introduction
• Generating Memory Helper T and B Cells
• Generating Memory Killer T Cells
• Strategies for Vaccine Development
• Will there be an Aids Vaccine?
• Vaccination to Prevent Virus-Associated Cancer
• Vaccine Adjuvants
• Lecture 15 Cancer and the Immune System
• Introduction
• Cancer is a Control System Problem
• Classification of Cancer Cells
• Immune Surveillance Against Cancer
• Immune Surveillance by Macrophages and NK Cells
• Lecture 16 Immunotherapy
• Introduction
• Immunotherapy Using Monoclonal Antibodies
• Immunotherapy Using T Cells
• Glossary
• List of Acronyms and Abbreviations
• Index
• End User License Agreement