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• Instructions for online access
• Cover image
• Title page
• Table of Contents
• Copyright
• Dedication
• Preface
• 1. Introduction to the Immune System: Nomenclature, General Properties, and Components
• Infections and Immunity
• Immunologic Disorders
• Stages of Host Defense: Innate and Adaptive Immunity
• Properties of Adaptive Immune Responses
• Cells of the Adaptive Immune System
• Tissues of the Immune System
• Summary
• 2. Unlabeled image.Innate Immunity: The Early Defense Against Infections
• General Features and Specificity of Innate Immune Responses
• Cellular Receptors for Microbes and Damaged Cells
• Components of Innate Immunity
• Innate Immune Reactions
• Role of Innate Immunity in Stimulating Adaptive Immune Responses
• Summary
• 3. Antigen Presentation to T Lymphocytes and the Functions of Major Histocompatibility Complex Molecules: What T Lymphocytes See
• Antigens Recognized by T Lymphocytes
• Capture of Protein Antigens by Antigen-Presenting Cells
• Structure and Function of Major Histocompatibility Complex Molecules
• Processing and Presentation of Protein Antigens
• Functions of Antigen-Presenting Cells in Addition to Antigen Display
• Antigen Recognition by Other T Lymphocytes
• Summary
• 4. Antigen Recognition in the Adaptive Immune System: Structure of Lymphocyte Antigen Receptors and Development of Immune Repertoires
• Antigen Receptors of Lymphocytes
• Development of B and T Lymphocytes
• Summary
• 5. T Cell–Mediated Immunity: Activation of T Lymphocytes
• Steps in T Cell Responses
• Antigen Recognition and Costimulation
• Biochemical Pathways of T Cell Activation
• Functional Responses of T Lymphocytes to Antigen and Costimulation
• Regulation of T Cell Responses by Inhibitory Receptors (Coinhibitors)
• Migration of T Lymphocytes in Cell-Mediated Immune Reactions
• Decline of the Immune Response
• Summary
• 6. Effector Mechanisms of T Cell–Mediated Immunity: Functions of T Cells in Host Defense
• Types of T Cell–Mediated Immune Reactions
• Development and Functions of CD4+ Effector T Lymphocytes
• Differentiation and Functions of CD8+ Cytotoxic T Lymphocytes
• Resistance of Pathogenic Microbes to Cell-Mediated Immunity
• Summary
• 7. Humoral Immune Responses: Activation of B Lymphocytes and Production of Antibodies
• Phases and Types of Humoral Immune Responses
• Stimulation of B Lymphocytes by Antigen
• Functions of Helper T Lymphocytes in Humoral Immune Responses
• Antibody Responses to T-Independent Antigens
• Regulation of Humoral Immune Responses
• Summary
• 8. Effector Mechanisms of Humoral Immunity: Elimination of Extracellular Microbes and Toxins
• Properties of Antibodies That Determine Effector Functions
• Neutralization of Microbes and Microbial Toxins
• Opsonization and Phagocytosis
• Antibody-Dependent Cellular Cytotoxicity
• Immunoglobulin E– and Mast Cell–Mediated Reactions
• The Complement System
• Functions of Antibodies at Special Anatomic Sites
• Evasion of Humoral Immunity by Microbes
• Vaccination
• Summary
• 9. Immunologic Tolerance and Autoimmunity: Self–Nonself Discrimination in the Immune System and Its Failure
• Immunologic Tolerance: General Priniciples and Significance
• Central T Lymphocyte Tolerance
• Peripheral T Lymphocyte Tolerance
• B Lymphocyte Tolerance
• Tolerance to Commensal Microbes and Fetal Antigens
• Autoimmunity
• Summary
• 10. Tumor and Transplantation Immunology: Immune Responses to Cancer Cells and Normal Foreign Cells
• Immune Responses Against Tumors
• Immune Responses Against Transplants
• Summary
• 11. Hypersensitivity: Disorders Caused by Immune Responses
• Types of Hypersensitivity Reactions
• Immediate Hypersensitivity
• Diseases Caused by Antibodies Specific for Cell and Tissue Antigens
• Diseases Caused by Antigen-Antibody Complexes
• Diseases Caused by T Lymphocytes
• Summary
• 12. Immunodeficiency Diseases: Disorders Caused by Defective Immunity
• Primary (Congenital) Immunodeficiencies
• Acquired (Secondary) Immunodeficiencies
• Acquired Immunodeficiency Syndrome (AIDS)
• Summary
• Appendix I. Principal Features of Selected CD Molecules
• Appendix II. Cytokines
• Appendix III. Clinical Cases
• Answers to Review Questions
• Index