Efnisyfirlit

• Cover image
• Title Page
• Table of Contents
• Endsheet
• Copyright
• Dedication
• Contributors
• Preface
• Acknowledgments
• Chapter 1 The Cell as a Unit of Health and Disease
• The Genome
• Cellular Housekeeping
• Cellular Metabolism and Mitochondrial Function
• Cellular Activation
• Growth Factors and Receptors
• Extracellular Matrix
• Maintaining Cell Populations
• Suggested Readings
• Chapter 2 Cell Injury, Cell Death, and Adaptations
• Introduction to Pathology
• Overview of Cellular Responses to Stress and Noxious Stimuli
• Reversible Cell Injury
• Cell Death
• Mechanisms of Cell Injury
• Clinicopathologic Correlations: Selected Examples of Cell Injury and DEATH
• Adaptations of Cellular Growth and Differentiation
• Intracellular Accumulations
• Pathologic Calcification
• Cellular Aging
• Suggested Readings
• Chapter 3 Inflammation and Repair
• Overview of Inflammation: Definitions and General Features
• Acute Inflammation
• Chronic Inflammation
• Systemic Effects of Inflammation
• Tissue Repair
• Suggested Readings
• Chapter 4 Hemodynamic Disorders, Thromboembolic Disease, and Shock
• Edema and Effusions
• Hyperemia and Congestion
• Hemostasis, Hemorrhagic Disorders, and Thrombosis
• Embolism
• Infarction
• Shock
• Suggested Readings
• Chapter 5 Genetic Disorders
• Genes and Human Diseases
• Mendelian Disorders
• Complex Multigenic Disorders
• Chromosomal Disorders
• Single-Gene Disorders With Nonclassic Inheritance
• Molecular Genetic Diagnosis
• Acknowledgment
• Suggested Readings
• Chapter 6 Diseases of the Immune System
• The Normal Immune Response
• Hypersensitivity: Immunologically Mediated Tissue Injury
• Autoimmune Diseases
• Rejection of Tissue Transplants
• Immunodeficiency Diseases
• Amyloidosis
• Suggested Readings
• Chapter 7 Neoplasia
• Nomenclature
• Characteristics of Benign and Malignant Neoplasms
• Epidemiology of Cancer
• Molecular Basis of Cancer: Role of Genetic and Epigenetic Alterations
• Carcinogenic Agents and Their Cellular Interactions
• Clinical Aspects of Neoplasia
• Suggested Readings
• Chapter 8 Infectious Diseases
• General Principles of Microbial Pathogenesis
• Viral Infections
• Bacterial Infections
• Fungal Infections
• Parasitic Infections
• Sexually Transmitted Infections
• Emerging Infectious Diseases
• Special Techniques for Diagnosing Infectious Agents
• Suggested Readings
• Chapter 9 Environmental and Nutritional Diseases
• Health Effects of Climate Change
• Toxicity of Chemical and Physical Agents
• Environmental Pollution
• Occupational Health Risks: Industrial and Agricultural Exposures
• Effects of Alcohol
• Injury by Therapeutic Drugs and Drugs of Abuse
• Injury by Physical Agents
• Nutritional Diseases
• Suggested Readings
• Chapter 10 Diseases of Infancy and Childhood
• Congenital Anomalies
• Prematurity and Fetal Growth Restriction
• Perinatal Infections
• Fetal Hydrops
• Inborn Errors of Metabolism and Other Genetic Disorders
• Sudden Infant Death Syndrome
• Tumors and Tumorlike Lesions of Infancy and Childhood
• Suggested Readings
• Chapter 11 Blood Vessels
• Vascular Structure and Function
• Vascular Anomalies
• Vascular Wall Response to Injury
• Hypertensive Vascular Disease
• Arteriosclerosis
• Atherosclerosis
• Aneurysms and Dissection
• Vasculitis
• Disorders of Blood Vessel Hyperreactivity
• Veins and Lymphatics
• Vascular Tumors
• Pathology of Vascular Intervention
• Suggested Readings
• Chapter 12 The Heart
• Cardiac Structure and Specializations
• Overview of Cardiac Pathophysiology
• Heart Failure
• Cardiac Development
• Congenital Heart Disease
• Ischemic Heart Disease
• Arrhythmias
• Hypertensive Heart Disease
• Valvular Heart Disease
• Cardiomyopathies
• Pericardial Disease
• Tumors of the Heart
• Cardiac Transplantation
• Cardiac Devices
• Suggested Readings
• Chapter 13 Diseases of White Blood Cells, Lymph Nodes, Spleen, and Thymus
• Normal Hematopoiesis
• Disorders of White Cells
• Spleen
• Thymus
• Suggested Readings
• Chapter 14 Red Blood Cell and Bleeding Disorders
• Anemias
• Polycythemia
• Bleeding Disorders: Hemorrhagic Diatheses
• Suggested Readings
• Chapter 15 The Lung
• Congenital Anomalies
• Atelectasis (Collapse)
• Pulmonary Edema
• Acute Lung Injury and Acute Respiratory Distress Syndrome (Diffuse Alveolar Damage)
• Obstructive and Restrictive Lung Diseases
• Obstructive Lung Diseases
• Chronic Diffuse Interstitial (Restrictive) Diseases
• Diseases of Vascular Origin
• Pulmonary Infections
• Lung Transplantation
• Tumors
• Pleura
• Suggested Readings
• Chapter 16 Head and Neck
• Oral Cavity
• Upper Airways
• Ears
• Neck
• Salivary Glands
• Suggested Readings
• Chapter 17 The Gastrointestinal Tract
• Congenital Abnormalities
• Esophagus
• Stomach
• Small Intestine and Colon
• Peritoneal Cavity
• Suggested Readings
• Chapter 18 Liver and Gallbladder
• The Liver and Bile Ducts
• Gallbladder
• Suggested Readings
• Chapter 19 The Pancreas
• Congenital Anomalies
• Pancreatitis
• Nonneoplastic Cysts
• Neoplasms
• Suggested Readings
• Chapter 20 The Kidney
• Clinical Manifestations of Renal Diseases
• Glomerular Diseases
• Tubular and Interstitial Diseases
• Vascular Diseases
• Congenital and Developmental Anomalies
• Cystic Diseases of the Kidney
• Urinary Tract Obstruction (Obstructive Uropathy)
• Urolithiasis (Renal Calculi, Stones)
• Neoplasms of the Kidney
• Suggested Readings
• Chapter 21 The Lower Urinary Tract and Male Genital System
• The Lower Urinary Tract
• The Male Genital Tract
• Suggested Readings
• Chapter 22 The Female Genital Tract
• Vulva
• Vagina
• Cervix
• Body of Uterus and Endometrium
• Ovaries
• Gestational and Placental Disorders
• Suggested Readings
• Chapter 23 The Breast
• Disorders of Development
• Clinical Presentations of Breast Disease
• Inflammatory Disorders
• Benign Epithelial Lesions
• Carcinoma of the Breast
• Stromal Tumors
• Other Malignant Tumors of the Breast
• Suggested Readings
• Chapter 24 The Endocrine System
• Pituitary Gland
• Thyroid Gland
• Parathyroid Glands
• The Endocrine Pancreas
• Adrenal Glands
• Multiple Endocrine Neoplasia Syndromes
• Pineal Gland
• Suggested Readings
• Chapter 25 The Skin
• The Skin: More Than a Mechanical Barrier
• Disorders of Pigmentation and Melanocytes
• Benign Epithelial Tumors
• Adnexal (Appendage) Tumors
• Premalignant and Malignant Epidermal Tumors
• Tumors of the Dermis
• Tumors of Cellular Migrants to the Skin
• Disorders of Epidermal Maturation
• Acute Inflammatory Dermatoses
• Chronic Inflammatory Dermatoses
• Blistering (Bullous) Diseases
• Disorders of Epidermal Appendages
• Panniculitis
• Infection
• Suggested Readings
• Chapter 26 Bones, Joints, and Soft Tissue Tumors
• Bone
• Joints
• Soft Tissue Tumors
• Suggested Readings
• Chapter 27 Peripheral Nerves and Skeletal Muscles
• Diseases of Peripheral Nerves
• Diseases of the Neuromuscular Junction
• Diseases of Skeletal Muscle
• Peripheral Nerve Sheath Tumors
• Suggested Readings
• Chapter 28 The Central Nervous System
• Cellular Pathology of the Central Nervous System
• Cerebral Edema, Hydrocephalus, Raised Intracranial Pressure, and Herniation
• Malformations and Developmental Disorders
• Perinatal Brain Injury
• Trauma
• Cerebrovascular Disease
• Infections
• Demyelinating Diseases
• Neurodegenerative Diseases
• Genetic Metabolic Diseases
• Toxic and Acquired Metabolic Diseases
• Tumors
• Acknowledgment
• Suggested Readings
• Chapter 29 The Eye
• Orbit
• Eyelid
• Conjunctiva
• Sclera
• Cornea
• Anterior Segment
• Uvea
• Retina and Vitreous
• Optic Nerve
• The End-Stage Eye: Phthisis Bulbi
• Suggested Readings
• Index