Efnisyfirlit

• Instructions for online access
• Cover image
• Title page
• Table of Contents
• Copyright
• Preface
• Preface to the first edition
• Acknowledgements
• List of Tables
• List of Illustrations
• 1. Basic principles
• 1.  Microanatomy of the skin
• Introduction
• Epidermis
• Dermis
• Subcutaneous layer
• 2.  Derivatives of the skin
• Hair
• Nails
• Sebaceous glands
• Sweat glands
• Other structures in skin
• 3.  Physiology of the skin
• Keratinocyte maturation
• Hair growth
• Melanocyte function
• Thermoregulation
• 4.  Biochemistry of the skin
• Keratins
• Melanins
• Collagens
• Glycosaminoglycans
• Skin surface secretions
• Subcutaneous fat
• Hormones and the skin
• 5.  Inflammation, immunity and the skin
• Microbiome
• Immunologically functional cells in the skin
• Hypersensitivity reactions and the skin
• 6.  Molecular genetics and the skin
• The human chromosomes
• Forms of inheritance
• Gene therapy
• 7.  Terminology of skin lesions
• Macule (see vitiligo, p. 92)
• Papule (see dermatofibroma, p. 115)
• Nodule (see squamous cell carcinoma, p. 124)
• Bulla (see pemphigoid, p. 96)
• Vesicle (see dermatitis herpetiformis, p. 96)
• Pustule (see acne, p. 80)
• Cyst (see acne, p. 80)
• Wheal (see urticaria, p. 94)
• Plaque (see psoriasis, p. 38)
• Scale (see psoriasis, p. 38)
• Ulcer (see venous leg ulcer, p. 90)
• 8.  Taking a history
• Presenting complaint
• Past medical history
• Social and occupational history
• Family history
• Drug history
• 9.  Examining the skin
• Distribution of eruption or lesions
• Morphology of individual lesions
• Nails, hair and mucous membranes
• General examination
• Special techniques and assessment of disease morbidity
• 10.  Practical clinic procedures
• Diagnostic procedures
• Therapeutic procedures
• 11.  Dermoscopy
• Contact dermoscopy
• Polarized dermsocopy
• Dermoscopic examination
• Dermoscopic algorithms
• Technology
• 12.  Basics of medical therapy—topical treatments
• Topical therapy
• 13.  Basics of medical therapy—systemic medication, other treatments, monitoring and scoring systems
• When to select systemic therapy
• Monitoring prescribed drug treatments
• Other treatments
• Scoring systems for skin diseases
• 14.  Epidemiology of skin disease
• Skin disease in the general population
• Skin disease in community and specialized clinics
• Socioeconomic factors
• Geographical factors
• Racial and cultural factors
• Age and sex prevalence of dermatoses
• 15.  Body image, the psyche and the skin
• The stress of having skin disease
• Skin disorders of psychogenic origin
• 2. Diseases
• Eruptions
• 16.  Psoriasis—epidemiology, pathophysiology and presentation
• Epidemiology
• Aetiopathogenesis
• Clinical presentation
• 17.  Psoriasis—topical treatment and disease complications
• Planning treatment
• Topical therapy
• When to move on to systemic treatments
• Complications of psoriasis
• 18.  Psoriasis—systemic treatments
• Non-biologic systemic therapy
• Biologics
• 19.  Eczema—acute, chronic and irritant
• Acute eczema (fig. 19.1)
• Chronic eczema (fig. 19.2)
• Irritant contact dermatitis
• 20.  Eczema—allergic contact dermatitis and patch testing
• Definition
• Aetiopathogenesis
• Clinical presentation
• Differential diagnosis
• Management
• Allergen avoidance
• Patch testing
• 21.  Eczema—atopic eczema
• Definition
• Aetiopathogenesis
• Clinical presentation
• Differential diagnosis
• Management
• 22.  Eczema—other forms
• Seborrhoeic dermatitis
• Hand dermatitis
• Pompholyx eczema (cheiropompholyx)
• Discoid (nummular) eczema
• Venous (stasis) eczema
• Asteatotic eczema (eczema craquelé)
• Other eczemas
• 23.  Lichenoid eruptions
• Lichen planus
• Lichen sclerosus
• Lichen nitidus
• Lichen planus-like drug eruption
• 24.  Papulosquamous eruptions
• Pityriasis rosea
• Pityriasis (tinea) versicolor
• Reiter’s disease
• Pityriasis lichenoides
• Chronic superficial scaly dermatitis
• Other pityriases
• Secondary syphilis
• 25.  Erythroderma
• Clinical presentation
• Management
• 26.  Photodermatology
• Photodermatoses—idiopathic
• Photodermatoses—other causes
• Dermatoses improved or worsened by sunlight
• Infections
• 27.  Bacterial infection—staphylococcal and streptococcal
• The normal skin microflora
• Staphylococcal infections
• Streptococcal infections
• 28.  Other bacterial infections
• Diseases due to commensal overgrowth
• Mycobacterial infections
• Spirochaetal infections
• Further bacterial infections
• 29.  Viral infections—warts and other viral infections
• Viral warts
• Other viral infections
• 30.  Viral infections—herpes simplex and herpes zoster
• Herpes simplex
• Herpes zoster
• 31.  Human immunodeficiency virus disease and immunodeficiency syndromes
• Human immunodeficiency virus disease
• Congenital immune deficiency syndromes
• Skin signs of immunosuppression for organ transplants
• 32.  Fungal infections
• Dermatophyte infections
• 33.  Yeast infections and related disorders
• Seborrhoeic dermatitis
• Pityriasis (tinea) versicolor
• Candida albicans infection
• 34.  Tropical infections and infestations
• Leprosy
• Leishmaniasis
• Larva migrans
• Deep mycoses
• Filariasis
• Onchocerciasis
• 35.  Infestations
• Insect bites
• Lice infestation (pediculosis)
• Scabies
• Disorders of specific skin structures
• 36.  Sebaceous and sweat glands—acne
• Acne
• 37.  Sebaceous and sweat glands—rosacea and other disorders
• Rosacea
• Perioral dermatitis
• Hidradenitis suppurativa
• Hyperhidrosis
• Other disorders of eccrine glands
• 38.  Disorders of hair
• Hair loss (alopecia)
• Diffuse non-scarring alopecia
• Localized non-scarring alopecia
• Localized/diffuse scarring alopecia
• Excess hair (hirsutism and hypertrichosis)
• Other disorders
• 39.  Disorders of nails
• Congenital disease
• Trauma
• Dermatoses
• Infections
• Systemic disease
• Tumours
• 40.  Vascular and lymphatic diseases
• Blood vessel disorders
• Lymphatic disorders
• 41.  Leg ulcers
• Venous disease
• Arterial disease
• Diabetic foot ulcers and other causes of leg ulcer
• 42.  Pigmentation
• Hypopigmentation
• Hyperpigmentation
• Allergy and autoimmunity
• 43.  Urticaria
• Aetiopathogenesis
• Clinical presentation
• Management
• 44.  Blistering disorders
• Pemphigus
• Pemphigoid
• Dermatitis herpetiformis
• Linear IgA disease
• 45.  Connective tissue diseases—lupus erythematosus and systemic sclerosis
• Lupus erythematosus
• Systemic sclerosis
• Morphoea
• Dermatomyositis
• Other connective tissue diseases
• Idiopathic arthritis including Still’s disease (juvenile and adult-onset) (antinuclear antibodies negative)
• Relapsing polychondritis (antinuclear antibodies negative)
• Sjögren’s syndrome (anti-Ro ∼70%; anti-La ∼50%)
• 46.  Vasculitis and the reactive erythemas
• Vasculitis
• Erythema multiforme
• Erythema nodosum
• Sweet’s disease
• Graft-versus-host disease
• Internal medicine
• 47.  Skin changes in internal conditions
• Skin signs of endocrine and metabolic disease
• Skin signs of nutritional and other internal disorders
• 48.  Drug eruptions
• Aetiopathogenesis
• Clinical presentation
• Differential diagnosis
• Management
• 49.  Associations with malignancy
• Conditions associated with malignancy
• Conditions occasionally associated with malignancy
• Inherited disorders
• 50.  Keratinization and blistering syndromes
• The ichthyoses
• Keratoderma
• Keratosis pilaris
• Darier’s disease
• Flegel’s disease
• Epidermolysis bullosa
• Prenatal diagnosis of inherited disorders
• 51.  Neurocutaneous disorders and other syndromes
• Neurofibromatosis
• Tuberous sclerosis complex
• Incontinentia pigmenti
• Xeroderma pigmentosum
• Ehlers–Danlos syndrome
• Pseudoxanthoma elasticum
• The premature ageing syndromes
• Skin tumours
• 52.  Benign tumours—epidermal and dermal
• Benign epidermal tumours
• Benign dermal tumours
• 53.  Benign tumours—dermal structures and appendages
• Benign tumours of vascular and connective tissue
• Benign tumours of the skin appendages
• 54.  Naevi
• Melanocytic naevi
• Epidermal naevi
• Connective tissue naevi
• 55.  Skin cancer—premalignant disorders
• Actinic keratoses
• Dysplastic naevi
• 56.  Skin cancer—basal cell carcinoma
• Aetiopathogenesis
• Clinical presentation
• Management (see also table 64.1)
• 57.  Skin cancer—squamous cell carcinoma
• Bowen’s disease (in situ squamous cell carcinoma)
• Keratoacanthoma
• Squamous cell carcinoma
• 58.  Skin cancer—malignant melanoma
• Superficial spreading malignant melanoma
• Lentigo malignant melanoma
• Acral lentiginous malignant melanoma
• Nodular malignant melanoma
• 59.  Cutaneous T-cell lymphomas, B-cell lymphomas and malignant dermal tumours
• Cutaneous T-cell lymphoma (mycosis fungoides)
• Lymphomatoid papulosis
• Primary cutaneous B-cell lymphoma
• Primary skin tumours of dermal origin
• Cutaneous metastatic deposits
• 60.  Ageing and photoageing of the skin
• Signs of photoageing
• Stages of photoageing
• Management of photoageing
• 3. Special topics in dermatology
• 61.  Biologics—their use in skin disease
• General principles
• Side effects of biologics
• Monitoring during treatment
• Psoriasis
• Use of biologics in other skin diseases
• 62.  Phototherapy
• The sun’s radiation spectrum
• Effects of light on normal skin
• Treatments
• Prophylaxis of photodermatoses
• Sunbeds
• 63.  Basic dermatological surgery
• Instruments and methods
• Basic surgical techniques
• Other surgical techniques
• 64.  Advanced dermatological surgery
• Simple plastic repairs
• Skin flaps
• Skin grafts
• Mohs’ micrographic surgery
• Anticoagulants and skin surgery
• Antiplatelet agents and skin surgery
• Lasers and intense pulsed light
• Photodynamic therapy
• 65.  Cosmetics and cosmetic procedures
• The range of cosmetics and their usage
• Reactions to cosmetics
• Cosmetic procedures
• 66.  Paediatric dermatology—childhood eczemas and other dermatoses
• Childhood eczemas and related disorders
• Other childhood dermatoses
• 67.  Paediatric dermatology—vascular naevi and dermatoses of the newborn
• Vascular tumours
• Vascular malformations
• Cutaneous disorders of the newborn
• 68.  The skin in old age
• Intrinsic ageing of the skin
• Dermatoses in the elderly
• 69.  The skin in pregnancy
• The skin during pregnancy
• Dermatoses in pregnancy
• 70.  Genitourinary infections
• Syphilis (lues)
• Gonorrhoea
• Other genitourinary infections
• 71.  Female genital dermatoses
• Normal variants of vulval anatomy
• Benign dermatoses
• Infections
• Neoplasia
• Genital ulceration and trauma
• Pain syndromes
• 72.  Male genital dermatoses and perianal skin diseases
• Normal variants
• Benign dermatoses
• Infections
• Neoplasia
• Genital ulceration and lymphedema
• Pain syndromes
• Perianal skin diseases
• 73.  Skin disease in people of colour
• Evolution of skin pigmentation
• Racial differences in hair and eye colour
• Diseases that show racially dependent variations
• Diseases with a distinct racial or ethnic predisposition
• 74.  Occupation and the skin
• Diagnosis
• Contact dermatitis
• Contact urticaria
• Vibration white finger
• Prevention
• 75.  Immunological tests
• Skin prick tests
• Patch testing
• Immunofluorescence
• Assays of T-cell function
• Bibliography and online resources
• Index