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• Cover image
• Title page
• Table of Contents
• Any screen, Any time, Anywhere
• Copyright
• Contributors
• Preface
• Dedication and Acknowledgments
• Section 1: Mechanisms of Drug Action and Therapeutic Principles
• 1. Introduction
• Website
• 2. Cellular Receptors and Drug Concentration–Response Relationships
• Abstract
• Biological Sites and Specificity of Drug Action
• General Properties of Cellular Receptors
• Agonists and Antagonists
• Receptor Families, Subtypes, and Signaling Cascades
• Quantitative Relationships
• Self-Assessment Questions
• Website
• 3. Pharmacokinetics
• Abstract
• Absorption and Distribution
• Metabolism and Elimination of Drugs
• Clinical Considerations
• Calculation of Pharmacokinetic Parameters
• Multiple or Prolonged Dosing
• Pharmacogenomics
• Special Populations and Disease Considerations
• Biologics
• Summary
• Self-Assessment Questions
• Further Reading
• 4. Pharmacogenetics
• Abstract
• Genes Affecting Pharmacokinetics: Drug Metabolism and Drug Transporters
• Genes Affecting Pharmacodynamics
• Cancer Pharmacogenetics
• Summary
• Self-Assessment Questions
• Further Reading
• Websites
• 5. Drug Discovery, Development, and Regulation
• Abstract
• Introduction
• Drug Discovery and Development
• Prescription Writing and Regulation
• Summary
• Terms
• Self-Assessment Questions
• Further Reading
• Websites
• Section 2: Chemical Mediators and Drugs Affecting Autonomic and Neuromuscular Synapses
• 6. Introduction to the Autonomic Nervous System
• Abstract
• Divisions of the Autonomic Nervous System
• Control of the Autonomic Nervous System
• Functional Responses Mediated by the Autonomic Nervous System
• Neurotransmission in the Autonomic Nervous System
• Neurotransmitters in the Autonomic Nervous System
• Neurotransmitter Receptors in the Autonomic Nervous System
• Drugs Affecting the Autonomic Nervous System
• New Developments
• Self-Assessment Questions
• Further Reading
• Websites
• Cholinergic Drugs
• 7. Muscarinic Agonists, Cholinesterase Inhibitors, and Their Clinical Uses
• Abstract
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Self-Assessment Questions
• Further Reading
• Websites
• 8. Muscarinic Antagonists and Their Clinical Uses
• Abstract
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Self-Assessment Questions
• Further Reading
• Website
• 9. Nicotinic Agonists and Their Clinical Uses
• Abstract
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• Clinical Relevance for Healthcare Professionals
• New Developments
• Self-Assessment Questions
• Further Reading
• Website
• 10. Neuromuscular Blocking Drugs and Nicotinic Antagonists
• Abstract
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Self-Assessment Questions
• Further Reading
• Website
• Adrenergic Drugs
• 11. Adrenergic Agonists and Their Clinical Uses
• Abstract
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Self-Assessment Questions
• Further Reading
• Websites
• 12. Adrenergic Antagonists and Their Clinical Uses
• Abstract
• Therapeutic Overview
• Mechanisms of Action
• Mixed-Action β1-Adrenergic Receptor Antagonist and β3-Adrenergic Receptor Agonist
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Self-Assessment Questions
• Further Reading
• Websites
• Section 3: Drug Treatment for Disorders Affecting the Central Nervous System
• 13. The Central Nervous System
• Abstract
• Introduction
• Neurotransmission in the Central Nervous System
• Organization of the Central Nervous System
• Drug Action in the Central Nervous System
• Self-Assessment Questions
• Further Reading
• Website
• 14. Drug Therapy for Alzheimer Disease and Other Cognitive Disorders/Dementias
• Abstract
• Therapeutic Overview
• Pathophysiology
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Self-Assessment Questions
• Further Reading
• Websites
• 15. Pharmacotherapy of Basal Ganglia Disorders: Parkinson Disease and Huntington Disease
• Abstract
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Self-Assessment Questions
• Further Reading
• Websites
• 16. Drug Therapy for Psychoses and Bipolar Disorder
• Abstract
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Self-Assessment Questions
• Further Reading
• Websites
• 17. Drug Therapy for Depression and Anxiety
• Abstract
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Self-Assessment Questions
• Further Reading
• Websites
• 18. Drug Therapy for the Management of Attention Deficit-Hyperactivity Disorder
• Abstract
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• Drug Use Disorder and Dependence
• New Developments
• Clinical Relevance for Healthcare Professionals
• Self-Assessment Questions
• Further Reading
• Websites
• 19. Drug Therapy for Insomnia and the Hypersomnias
• Abstract
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Self-Assessment Questions
• Further Reading
• Websites
• 20. Drug Therapy for Managing Obesity and Eating Disorders
• Abstract
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Self-Assessment Questions
• Further Reading
• Websites
• 21. Treatment of Seizure Disorders
• Abstract
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Self-Assessment Questions
• Further Reading
• Websites
• 22. Drug Therapy for Spasticity Disorders
• Abstract
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Self-Assessment Questions
• Further Reading
• Websites
• 23. Ethanol, Other Alcohols, and Medications for Alcohol Use Disorder
• Abstract
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Self-Assessment Questions
• Further Reading
• Website
• 24. Psychoactive Compounds and Substance Use Disorder
• Abstract
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Self-Assessment Questions
• Further Reading
• Websites
• Section 4: Drug Therapy for Pain Management
• 25. Introduction
• Abstract
• Neurophysiology of Pain
• Specific Pain Syndromes
• Further Reading
• Website
• 26. General Anesthetics
• Abstract
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Self-Assessment Questions
• Further Reading
• Website
• 27. Local Anesthetics
• Abstract
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Practitioners
• Self-Assessment Questions
• Further Reading
• Websites
• 28. Opioid Analgesics
• Abstract
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Self-Assessment Questions
• Further Reading
• Websites
• 29. Nonsteroidal Antiinflammatory Drugs and Acetaminophen
• Abstract
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Self-Assessment Questions
• Further Reading
• Websites
• 30. Cannabinoids
• Abstract
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Self-Assessment Questions
• Further Reading
• Website
• 31. Drug Therapy for Migraine Headache
• Abstract
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Self-Assessment Questions
• Further Reading
• Websites
• Section 5: Treatment of Inflammatory, Allergic and Immunologic Disorders
• 32. Drug Therapy for Gout and Hyperuricemia
• Abstract
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Self-Assessment Questions
• Further Reading
• Websites
• 33. Pharmacological Interventions for Allergic Reactions
• Abstract
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Self-Assessment Questions
• Further Reading
• Websites
• 34. Immunosuppressants for Autoimmune Disorders and Organ Transplantation
• Abstract
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Self-Assessment Questions
• Further Reading
• Websites
• 35. Drug Therapy for Rheumatoid Arthritis
• Abstract
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Self-Assessment Questions
• Further Reading
• Websites
• Section 6: Drug Treatment for Cardiovascular Diseases
• 36. Introduction to the Regulation of Cardiovascular Function
• Abstract
• Central Control of Autonomic Nerve Activity
• Regulation of Sympathetic Activity
• Further Reading
• Self-Assessment Questions
• Websites
• 37. Overview of Hypertension Management and Drugs That Decrease Sympathetic Tone
• Abstract
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Self-Assessment Questions
• Further Reading
• 38. Diuretics and Drugs That Affect Volume and Electrolyte Content
• Abstract
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Self-Assessment Questions
• Further Reading
• Website
• 39. Drugs Affecting the Renin-Angiotensin-Aldosterone System
• Abstract
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Self-Assessment Questions
• Further Reading
• Websites
• 40. Calcium-Channel Blockers
• Abstract
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Self-Assessment Questions
• Further Reading
• Websites
• 41. Vasodilators for Hypertensive Crises, Pulmonary Hypertension, and Erectile Dysfunction
• Abstract
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Self-Assessment Questions
• Further Reading
• Websites
• 42. Treatment of Hyperlipidemias and Atherosclerotic Cardiovascular Disease
• Abstract
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Self-Assessment Questions
• Further Reading
• Website
• 43. Treatment of Myocardial Ischemia and Angina Pectoris
• Abstract
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Self-Assessment Questions
• Further Reading
• Websites
• 44. Treatment of Heart Failure
• Abstract
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Self-Assessment Questions
• Further Reading
• Websites
• 45. Antiarrhythmic Drugs
• Abstract
• Therapeutic Overview
• Cardiac Electrophysiology
• Mechanisms of Action of Antiarrhythmic Drugs
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Self-Assessment Questions
• Further Reading
• Website
• 46. Anticoagulant, Antiplatelet, and Fibrinolytic Medications
• Abstract
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Self-Assessment Questions
• Further Reading
• Websites
• 47. Drug Therapy for Hemophilia and the Deficiency Anemias
• Abstract
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Self-Assessment Questions
• Further Reading
• Websites
• Section 7: Treatment of Endocrine Disorders
• 48. Introduction to Endocrine Pharmacology
• Abstract
• Introduction
• Hormones
• New Developments
• Clinical Relevance for Healthcare Professionals
• 49. Treatment of Hypothalamic and Pituitary Disorders
• Abstract
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Self-Assessment Questions
• Further Reading
• Websites
• 50. Diagnosis and Treatment of Adrenocorticosteroid Disorders
• Abstract
• Therapeutic Overview
• Mechanisms of Action
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Self-Assessment Questions
• Further Reading
• Websites
• 51. Female Hormone Regulation
• Abstract
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Self-Assessment Questions
• Further Reading
• Websites
• 52. Androgens, Antiandrogens, and Their Clinical Uses
• Abstract
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Self-Assessment Questions
• Further Reading
• Website
• 53. Drug Therapy for the Management of Diabetes
• Abstract
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Self-Assessment Questions
• Further Reading
• Websites
• 54. Drug Therapy for the Management of Thyroid Disorders
• Abstract
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Self-Assessment Questions
• Further Reading
• Website
• 55. Calcium Regulating Hormones and Other Agents Affecting Bone
• Abstract
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Self-Assessment Questions
• Further Reading
• Websites
• Section 8: Chemotherapy
• Infectious Diseases
• 56. Principles of Antimicrobial Use
• Abstract
• Introduction
• Drug-Bacteria Interactions
• Host-Bacteria Interactions
• Drug-Host Interactions
• Antimicrobial Therapy
• Self-Assessment Questions
• Further Reading
• Websites
• 57. Drugs Targeting Bacterial Cell Walls and Membranes
• Abstract
• Therapeutic Overview
• Mechanisms of Action
• Mechanisms of Resistance
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Self-Assessment Questions
• Further Reading
• Websites
• 58. Drugs Targeting Bacterial Protein Synthesis
• Abstract
• Therapeutic Overview
• Mechanisms of Action
• Mechanisms of Resistance
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Self-Assessment Questions
• Further Reading
• Website
• 59. Drugs Targeting Bacterial DNA
• Abstract
• Therapeutic Overview
• Mechanisms of Action
• Mechanisms of Resistance
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Self-Assessment Questions
• Further Reading
• Websites
• 60. Antimycobacterial Agents
• Abstract
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Self-Assessment Questions
• Further Reading
• Websites
• 61. Drugs Targeting Resistant Organisms
• Abstract
• Therapeutic Overview
• Multidrug-Resistant Gram-Positive Bacteria
• Multidrug-Resistant Gram-Negative Bacteria
• New Developments
• Clinical Relevance for Healthcare Professionals
• Self-Assessment Questions
• Further Reading
• Websites
• Parasitic Diseases
• 62. Antifungal Agents
• Abstract
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Self-Assessment Questions
• Further Reading
• Website
• 63. Antimalarial and Other Antiprotozoal Agents
• Abstract
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Self-Assessment Questions
• Further Reading
• Websites
• 64. Anthelmintics and Ectoparasiticides
• Abstract
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Self-Assessment Questions
• Further Reading
• Websites
• Viruses
• 65. Antiviral Agents
• Abstract
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Self-Assessment Questions
• Further Reading
• Websites
• 66. Antiretroviral Drugs for HIV
• Abstract
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Self-Assessment Questions
• Further Reading
• Websites
• Cancer
• 67. Principles of Cancer and Antineoplastic Drug Use
• Abstract
• Overview
• Cancer in the Clinic
• Biology of Cancer
• Treatment of Cancer
• Common Problems in the Treatment of Cancer
• New Developments
• Self-Assessment Questions
• Further Reading
• Websites
• 68. Cytotoxic Agents
• Abstract
• Therapeutic Overview
• Mechanisms of Action
• Mechanisms of Resistance
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Self-Assessment Questions
• Further Reading
• Websites
• 69. Targeted Anticancer Agents
• Abstract
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Self-Assessment Questions
• Further Reading
• Websites
• 70. Immunological and Cell-Based Therapies
• Abstract
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Self-Assessment Questions
• Further Reading
• Websites
• Section 9: Special Considerations
• 71. Therapeutic Use of Hematopoietic Growth Factors
• Abstract
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Self-Assessment Questions
• Further Reading
• Websites
• 72. Gastrointestinal Disorders and Their Treatment
• Abstract
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Self-Assessment Questions
• Further Reading
• Websites
• 73. Pharmacological Interventions for Asthma and Chronic Obstructive Pulmonary Disorders
• Abstract
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Self-Assessment Questions
• Further Reading
• Websites
• 74. Dietary Supplements, Nutraceuticals, and Natural Products
• Abstract
• Therapeutic Overview
• Mechanisms of Action
• Pharmacokinetics
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacovigilance: Side Effects, Clinical Problems, and Toxicity
• New Developments
• Clinical Relevance for Healthcare Professionals
• Self-Assessment Questions
• Further Reading
• Websites
• 75. Essentials of Toxicology
• Abstract
• Toxicology Overview
• Mechanisms of Action
• Toxicant Interactions
• Emerging Issues
• Clinical Relevance for Healthcare Professionals
• Self-Assessment Questions
• Further Reading
• Websites
• 76. Therapeutic Considerations for Pregnant, Pediatric, Geriatric, and Obese Individuals
• Abstract
• Therapeutic Overview
• Relationship of Population Characteristics to Drug Responses
• New Developments
• Clinical Relevance for Healthcare Professionals
• Self-Assessment Questions
• Further Reading
• Websites
• Appendix
• Answers to Self-Assessment Questions
• Index
• Confidence is ClinicalKey