Efnisyfirlit

• Instructions for online access
• Cover image
• Title Page
• Table of Contents
• Copyright
• Contributors
• Preface
• Dedication and Acknowledgments
• Section 1 Mechanisms of Drug Action and Therapeutic Principles
• Introduction
• 1 Introduction
• Websites
• 2 Pharmacodynamics
• Biological Sites and Specificity of Drug Action
• General Properties of Cellular Receptors
• Agonists and Antagonists
• Receptor Families, Subtypes, and Signaling Cascades
• Quantitative Relationships
• Receptor Regulation
• Websites
• Self-Assessment Questions
• 3 Pharmacokinetics
• Absorption and Distribution
• Metabolism and Elimination of Drugs
• Clinical Considerations
• Calculation of Pharmacokinetic Parameters
• Multiple or Prolonged Dosing
• Special Populations and Disease Considerations
• Summary
• Further Reading
• Self-Assessment Questions
• 4 Pharmacogenetics
• Genes Affecting Pharmacokinetics: Drug Metabolism and Drug Transporters
• Genes Affecting Pharmacodynamics
• Cancer Pharmacogenetics
• Summary
• Further Reading
• Websites
• Self-Assessment Questions
• 5 Drug Discovery, Development, and Regulation
• Drug Discovery and Development
• Prescription Writing and Regulation
• Summary
• Further Reading
• Websites
• Self-Assessment Questions
• Section 2 Chemical Mediators and Drugs Affecting Autonomic and Neuromuscular Synapses
• Introduction
• 6 Introduction to the Autonomic Nervous System
• Divisions of the Autonomic Nervous System
• Functional Responses Mediated by the Autonomic Nervous System
• Neurotransmission in the Autonomic Nervous System
• Neurotransmitters in the Autonomic Nervous System
• Neurotransmitter Receptors in the Autonomic Nervous System
• Drugs Affecting the Autonomic Nervous System
• New Developments
• Further Reading
• Websites
• Self-Assessment Questions
• Cholinergic Drugs
• 7 Muscarinic Agonists, Cholinesterase Inhibitors, and Their Clinical Uses
• TheRapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Further Reading
• Websites
• Self-Assessment Questions
• 8 Muscarinic Antagonists and Their Clinical Uses
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Further Reading
• Websites
• Self-Assessment Questions
• 9 Nicotinic Agonists and Their Clinical Uses
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• Clinical Relevance for Healthcare Professionals
• New Developments
• Further Reading
• Websites
• Self-Assessment Questions
• 10 Neuromuscular Blocking Drugs and Nicotinic Antagonists
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Further Reading
• Websites
• Self Assessment Questions
• Adrenergic Drugs
• 11 Adrenergic Agonists and Their Clinical Uses
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Further Reading
• Websites
• Self-Assessment Questions
• 12 Adrenergic Antagonists and Their Clinical Uses
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Further Reading
• Websites
• Self-Assessment Questions
• Section 3 Drug Treatment for Disorders Affecting the Central Nervous System
• Introduction
• 13 The Central Nervous System
• Introduction
• Neurotransmission in the Central Nervous System
• Organization of the Central Nervous System
• Drug Action in the Central Nervous System
• Further Reading
• Websites
• Self-Assessment Questions
• 14 Drug Therapy for Alzheimer Disease and Other Cognitive Disorders/Dementias
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Further Reading
• Websites
• Self-Assessment Questions
• 15 Pharmacotherapy of Basal Ganglia Disorders
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Further Reading
• Websites
• Self-Assessment Questions
• 16 Drug Therapy for Psychoses and Bipolar Disorder
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Further Reading
• Websites
• Self-Assessment Questions
• 17 Drug Therapy for Depression and Anxiety
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Further Reading
• Websites
• Self-Assessment Questions
• 18 Drug Therapy for the Management of Attention Deficit-Hyperactivity Disorder
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Further Reading
• Websites
• Self-Assessment Questions
• 19 Drug Therapy for Insomnia and the Hypersomnias
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Further Reading
• Websites
• Self-Assessment Questions
• 20 Drug Therapy for Managing Obesity and Eating Disorders
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Further Reading
• Websites
• Self-Assessment Questions
• 21 Treatment of Seizure Disorders
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Further Reading
• Websites
• Self-Assessment Questions
• 22 Drug Therapy for Spasticity Disorders
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Further Reading
• Websites
• Self-Assessment Questions
• 23 Ethanol, Other Alcohols, and Drugs for Alcohol Use Disorder
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Further Reading
• Websites
• Self-Assessment Questions
• 24 Illicit Psychoactive Compounds and Substance Use Disorder
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Further Reading
• Websites
• Self-Assessment Questions
• Section 4 Drug Therapy for Pain Management
• Introduction
• 25 Introduction
• Neurophysiology of Pain
• Drugs to Alleviate Pain
• Specific Pain Syndromes
• Further Reading
• Websites
• 26 General Anesthetics
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Further Reading
• Websites
• Self-Assessment Questions
• 27 Local Anesthetics
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Further Reading
• Websites
• Self-Assessment Questions
• 28 Opioid Analgesics
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Further Reading
• Websites
• Self-Assessment Questions
• 29 Nonsteroidal Antiinflammatory Agents and Acetaminophen
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Further Reading
• Websites
• Self-Assessment Questions
• 30 Cannabinoids as Analgesics
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Further Reading
• Website
• Self-Assessment Questions
• Section 5 Treatment of Inflammatory, Allergic and Immunological Disorders
• Introduction
• 31 Drug Therapy for Migraine Headache
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Further Reading
• Websites
• Self-Assessment Questions
• 32 Drug Therapy for Gout and Hyperuricemia
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Further Reading
• Websites
• Self-Assessment Questions
• 33 Drug Treatment for Allergic Reactions
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Further Reading
• Websites
• Self-Assessment Questions
• 34 Immunosuppressants for Autoimmune Disorders and Organ Transplantation
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Further Reading
• Websites
• Self Assessment Questions
• 35 Drug Therapy for Rheumatoid Arthritis
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Further Reading
• Websites
• Self-Assessment Questions
• Section 6 Drug Treatment for Cardiovascular Diseases
• Introduction
• 36 Introduction to the Regulation of Cardiovascular Function
• Central Control of Autonomic Nerve Activity
• Regulation of Sympathetic Activity
• Further Reading
• Websites
• Self-Assessment Questions
• 37 Overview of Hypertension Management and Drugs That Decrease Sympathetic Tone
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Further Reading
• Websites
• Self-Assessment Questions
• 38 Diuretics and Drugs That Affect Volume and Electrolyte Content
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Further Reading
• Websites
• Self-Assessment Questions
• 39 Drugs Affecting the Renin-Angiotensin-Aldosterone System
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Further Reading
• Websites
• Self-Assessment Questions
• 40 Calcium Channel Blockers
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Further Reading
• Websites
• Self-Assessment Questions
• 41 Vasodilators for Hypertensive Crises, Pulmonary Hypertension, and Erectile Dysfunction
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Further Reading
• Websites
• Self-Assessment Questions
• 42 Drug Therapy for Hyperlipidemias and Atherosclerotic Cardiovascular Disease
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Further Reading
• Websites
• Self-Assessment Questions
• 43 Drug Therapy for Myocardial Ischemia and Angina Pectoris
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Further Reading
• Websites
• Self-Assessment Questions
• 44 Treatment of Heart Failure
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Further Reading
• Websites
• Self-Assessment Questions
• 45 Antiarrhythmic Drugs
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Further Reading
• Websites
• Self-Assessment Questions
• 46 Anticoagulant, Fibrinolytic, and Antiplatelet Agents
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Further Reading
• Websites
• Self-Assessment Questions
• 47 Drug Therapy for Hemophilia and the Deficiency Anemias
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Further Reading
• Websites
• Self-Assessment Questions
• Section 7 Endocrine Pharmacology
• Introduction
• 48 Introduction to Endocrine Pharmacology
• Introduction
• Hormones
• New Developments
• Clinical Relevance for Healthcare Professionals
• 49 Treatment of Hypothalamic and Pituitary Disorders
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Further Reading
• Websites
• Self-Assessment Questions
• 50 Treatment of Adrenocorticosteroid Disorders
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Further Reading
• Websites
• Self-Assessment Questions
• 51 Female Hormone Regulation
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Further Reading
• Websites
• Self-Assessment Questions
• 52 Androgens, Antiandrogens, and Their Clinical Uses
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Further Reading
• Websites
• Self-Assessment Questions
• 53 Drug Therapy for the Management of Diabetes
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Further Reading
• Websites
• Self-Assessment Questions
• 54 Drug Therapy for the Management of Thyroid Disorders
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Further Reading
• Websites
• Self-Assessment Questions
• 55 Calcium Regulating Hormones and Other Agents Affecting Bone
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Further Reading
• Websites
• Self-Assessment Questions
• Section 8 Chemotherapy
• Introduction
• Infectious Diseases
• 56 Principles of Antimicrobial Use
• Introduction
• Drug-Bacteria Interactions
• Host-Bacteria Interactions
• Drug-Host Interactions
• Antimicrobial Therapy
• Further Reading
• Websites
• Self-Assessment Questions
• 57 Drugs Targeting Bacterial Cell Walls and Membranes
• Therapeutic Overview
• Mechanisms of Action
• Mechanisms of Resistance
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Further Reading
• Websites
• Self-Assessment Questions
• 58 Drugs Targeting Bacterial Protein Synthesis
• Therapeutic Overview
• Mechanisms of Action
• Mechanisms of Resistance
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Further Reading
• Websites
• Self-Assessment Questions
• 59 Drugs Targeting Bacterial DNA
• Therapeutic Overview
• Mechanisms of Action
• Mechanisms of Resistance
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Further Reading
• Websites
• Self-Assessment Questions
• 60 Antimycobacterial Agents
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Further Reading
• Websites
• Self-Assessment Questions
• 61 Drugs Targeting Resistant Organisms
• Therapeutic Overview
• Multidrug-Resistant Gram-Positive Bacteria
• Multidrug-Resistant Gram-Negative Bacteria
• New Developments
• Clinical Relevance for Healthcare Professionals
• Further Reading
• Websites
• Self-Assessment Questions
• Parasitic Diseases
• 62 Antifungal Agents
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Further Reading
• Websites
• Self-Assessment Questions
• 63 Antimalarial and Other Antiprotozoal Agents
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Further Reading
• Websites
• Self-Assessment Questions
• 64 Anthelmintics and Ectoparasiticides
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Further Reading
• Websites
• Self-Assessment Questions
• Viruses
• 65 Antiviral Agents
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Further Reading
• Websites
• Self-Assessment Questions
• 66 Antiretroviral Drugs for HIV
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Further Reading
• Websites
• Self-Assessment Questions
• Cancer
• 67 Principles of Antineoplastic Drug Use
• Therapeutic Overview
• Drug Selection and Issues
• Special Clinical Problems
• New Developments
• Further Reading
• Websites
• Self-Assessment Questions
• 68 Cytotoxic Agents
• Therapeutic Overview
• Mechanisms of Action
• Mechanisms of Resistance
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Further Reading
• Websites
• Self-Assessment Questions
• 69 Targeted Anticancer Agents
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Further Reading
• Websites
• Self-Assessment Questions
• Section 9 Special Considerations
• Introduction
• 70 Therapeutic Use of Hematopoietic Growth Factors
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Further Reading
• Websites
• Self-Assessment Questions
• 71 Gastrointestinal Disorders and Their Treatment
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Further Reading
• Websites
• Self-Assessment Questions
• 72 Pharmacological Treatment of Asthma and COPD
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Further Reading
• Websites
• Self-Assessment Questions
• 73 The Role of Nutraceuticals and Natural Products
• Therapeutic Overview
• Mechanisms of Action
• Relationship of Mechanisms of Action to Clinical Response
• Pharmacokinetics
• Pharmacovigilance: Adverse Effects and Drug Interactions
• New Developments
• Clinical Relevance for Healthcare Professionals
• Further Reading
• Websites
• Self-Assessment Questions
• 74 Essentials of Toxicology
• Toxicology Overview
• Mechanisms of Action
• Toxicant Interactions
• Emerging Issues
• Clinical Relevance for Healthcare Professionals
• Further Reading
• Websites
• Self-Assessment Questions
• 75 Therapeutic Considerations for Pregnant, Pediatric, Geriatric, and Obese Individuals
• Therapeutic Overview
• Relationship of Population Characteristics to Drug Responses
• Further Reading
• Websites
• Self-Assessment Questions
• Appendix
• Answers to Self-Assessment Questions
• Index