Efnisyfirlit

• Instructions for online access
• Cover
• Title page
• Table of Contents
• Copyright
• Dedication
• Preface
• Chapter 1: Properties and Overview of Immune Responses
• Innate and Adaptive Immunity
• Types of Adaptive Immune Responses
• Cardinal Features of Adaptive Immune Responses
• Cellular Components of the Adaptive Immune System
• Cytokines, Soluble Mediators of the Immune System
• Overview of Immune Responses to Microbes
• Summary
• Chapter 2: Cells and Tissues of the Immune System
• Cells of the Immune System
• Anatomy and Functions of Lymphoid Tissues
• Summary
• Chapter 3: Leukocyte Migration into Tissues
• Adhesion Molecules on Leukocytes and Endothelial Cells Involved in Leukocyte Recruitment
• Chemokines and Chemokine Receptors
• Leukocyte-Endothelial Interactions and Leukocyte Extravasation
• Migration of Neutrophils and Monocytes to Sites of Infection or Tissue Injury
• Migration and Recirculation of T Lymphocytes
• Migration of B Lymphocytes
• Summary
• Chapter 4: Innate Immunity
• Recognition of Microbes and Damaged Self by the Innate Immune System
• Cell-Associated Pattern Recognition Receptors of Innate Immunity
• Cellular Components of the Innate Immune System
• Soluble Recognition and Effector Molecules of Innate Immunity
• The Inflammatory Response
• The Antiviral Response
• Stimulation of Adaptive Immunity
• Feedback Mechanisms that Regulate Innate Immunity
• Summary
• Chapter 5: Antibodies and Antigens
• Antibody Structure
• Synthesis, Assembly, and Expression of Ig Molecules
• Antibody Binding of Antigens
• Structure-Function Relationships in Antibody Molecules
• Summary
• Chapter 6: Major Histocompatibility Complex Molecules and Antigen Presentation to T Lymphocytes
• Properties of Antigens Recognized by T Lymphocytes
• Antigen Capture and the Functions of Antigen-Presenting Cells
• The Major Histocompatibility Complex (MHC)
• Processing of Protein Antigens
• Presentation of Nonprotein Antigens to subsets of T Cells
• Summary
• Chapter 7: Immune Receptors and Signal Transduction
• An Overview of Signal Transduction
• The Immune Receptor Family
• The B Lymphocyte Antigen Receptor Complex
• The Attenuation of Immune Receptor Signaling
• Cytokine Receptors and Signaling
• Summary
• Chapter 8: Lymphocyte Development and Antigen Receptor Gene Rearrangement
• Overview of Lymphocyte Development
• Rearrangement of Antigen Receptor Genes in B and T Lymphocytes
• B Lymphocyte Development
• Maturation of T Lymphocytes
• Summary
• Chapter 9: Activation of T Lymphocytes
• Overview of T Lymphocyte Activation
• Signals for T Lymphocyte Activation
• Functional Responses of T Lymphocytes
• Decline of T Cell Responses
• Summary
• Chapter 10: Effector Mechanisms of Cell-Mediated Immunity
• Types of Cell-Mediated Immune Reactions
• Migration of Effector T Lymphocytes to Sites of Infection
• Effector Functions of CD4+ Helper T Cells
• Effector Functions of CD8+ Cytotoxic T Lymphocytes
• Functions of Other T Cell Subsets
• Summary
• Chapter 11: B Cell Activation and Antibody Production
• General Features of Humoral Immune Responses
• Antigen Recognition and Antigen-Induced B Cell Activation
• Helper T Cell–Dependent Antibody Responses to Protein Antigens
• Antibody Responses to T Cell–Independent Antigens
• Antibody Feedback: Regulation of Humoral Immune Responses by Fc Receptors
• Summary
• Chapter 12: Effector Mechanisms of Humoral Immunity
• Overview of Humoral Immunity
• Neutralization of Microbes and Microbial Toxins
• Antibody-Mediated Opsonization and Phagocytosis
• The Complement System
• Neonatal Immunity
• Summary
• Chapter 13: Regional Immunity: Specialized Immune Responses in Epithelial and Immune Privileged Tissues
• General Features of Immunity at Epithelial Barriers
• Immunity in the Gastrointestinal System
• Immunity in other Mucosal Tissues
• The Cutaneous Immune System
• Immune Privileged Tissues
• Summary
• Chapter 14: Immunologic Tolerance and Autoimmunity
• General Features of Immunologic Tolerance
• T Lymphocyte Tolerance
• B Lymphocyte Tolerance
• Tolerance induced by Foreign Protein Antigens
• Pathogenesis of Autoimmunity
• Summary
• Chapter 15: Immunity to Microbes
• General Features of Immune Responses to Microbes
• Immunity to Extracellular Bacteria
• Immunity to Intracellular Bacteria
• Immunity to Fungi
• Immunity to Viruses
• Immunity to Parasites
• Strategies for Vaccine Development
• Summary
• Chapter 16: Transplantation Immunology
• Immune Responses to Allografts
• Patterns and Mechanisms of Allograft Rejection
• Prevention and Treatment of Allograft Rejection
• Xenogeneic Transplantation
• Blood Transfusion and the ABO and Rh Blood Group Antigens
• Hematopoietic Stem Cell Transplantation
• Summary
• Chapter 17: Immunity to Tumors
• General Features of Tumor Immunity
• Tumor Antigens
• Immune Responses to Tumors
• Evasion of Immune Responses by Tumors
• Immunotherapy for Tumors
• The Role of the Immune System in Promoting Tumor Growth
• Summary
• Chapter 18: Hypersensitivity Disorders
• Causes of Hypersensitivity Diseases
• Mechanisms and Classification of Hypersensitivity Reactions
• Diseases Caused by Antibodies
• Diseases Caused by T Lymphocytes
• Therapeutic Approaches for Immunologic Diseases
• Selected Immunologic Diseases: pathogenesis and therapeutic strategies
• Summary
• Chapter 19: IgE-Dependent Immune Responses and Allergic Disease
• General Features of IgE-Dependent Immune Reactions
• Production of IgE
• Role of Mast Cells, Basophils, and Eosinophils in Immediate Hypersensitivity
• IgE- and Mast Cell–Dependent Reactions
• Genetic Susceptibility to Immediate Hypersensitivity
• ALLERGIC Diseases in Humans: Pathogenesis and Therapy
• The Protective Roles of IgE- and Mast Cell–Mediated Immune Reactions
• Summary
• Chapter 20: Congenital and Acquired Immunodeficiencies
• General Features of Immunodeficiency Diseases
• Congenital (Primary) Immunodeficiencies
• Acquired (Secondary) Immunodeficiencies
• Human Immunodeficiency Virus And The Acquired Immunodeficiency Syndrome
• Summary
• Glossary
• Cytokines
• Principal Features of Selected CD Molecules
• Laboratory Techniques Commonly Used in Immunology
• Index