Efnisyfirlit

• Instructions for online access
• Cover image
• Title page
• Table of Contents
• Copyright
• Dedication
• Preface
• Online Resources for Instructors and Students
• Chapter 1. Properties and Overview of Immune Responses
• Innate and Adaptive Immunity
• Innate Immunity
• Adaptive Immunity
• Summary
• Chapter 2. Cells and Tissues of the Immune System
• Cells of the Immune System
• Anatomy and Functions of Lymphoid Tissues
• Summary
• Chapter 3. Leukocyte Circulation and Migration Into Tissues
• Overview of Leukocyte Migration
• Adhesion Molecules on Leukocytes and Endothelial Cells Involved in Leukocyte Recruitment
• Chemokines and Chemokine Receptors
• Leukocyte-Endothelial Interactions and Leukocyte Recruitment into Tissues
• Migration of Neutrophils and Monocytes to Sites of Infection or Tissue Injury
• Migration and Recirculation of T Lymphocytes
• Migration of B Lymphocytes
• Summary
• Chapter 4. Innate Immunity
• Overview of Innate Immunity
• Recognition of Microbes and Damaged Tissue by the Innate Immune System
• Cellular Pattern Recognition Receptors
• Cellular Components of the Innate Immune System
• Soluble Effector Molecules of Innate Immunity
• The Inflammatory Response
• The Antiviral Response
• Stimulation of Adaptive Immunity
• Mechanisms that Limit Innate Immune Responses
• Summary
• Chapter 5. Antibodies and Antigens
• Antibody Structure
• Synthesis, Assembly, and Expression of Immunoglobulin Molecules
• Antibody Binding of Antigens
• Structure-Function Relationships in Antibody Molecules
• Summary
• Chapter 6. Antigen Presentation to T Lymphocytes and the Function of Major Histocompatibility Complex Molecules
• Properties of Antigens Recognized by T Lymphocytes
• Antigen Capture and the Functions of Antigen-Presenting Cells
• The Major Histocompatibility Complex
• Processing of Protein Antigens
• Presentation of Nonprotein Antigens to T Cells
• Summary
• Chapter 7. Immune Receptors and Signal Transduction
• Overview of Signal Transduction
• The Immune Receptor Family
• The T Cell Receptor Complex and T Cell Signaling
• The B Lymphocyte Antigen Receptor Complex
• The Attenuation of Immune Receptor Signaling
• Cytokine Receptors and Signaling
• Summary
• Chapter 8. Lymphocyte Development and Antigen Receptor Gene Rearrangement
• Overview of Lymphocyte Development
• Rearrangement of Antigen Receptor Genes in B and T Lymphocytes
• B Lymphocyte Development
• T Lymphocyte Development
• Summary
• Chapter 9. Activation of T Lymphocytes
• Overview of T Lymphocyte Activation
• Signals for T Lymphocyte Activation
• Functional Responses of T Lymphocytes
• Decline of T Cell Responses
• Summary
• Chapter 10. Differentiation and Functions of CD4+ Effector T Cells
• Overview of CD4+ T Cell–Mediated Immune Responses
• Subsets of CD4+ Effector T Cells
• The Th1 Subset
• The Th2 Subset
• The Th17 Subset
• Functions of Other HELPER T Cell Subsets
• Summary
• Chapter 11. Differentiation and Functions of CD8+ Effector T Cells
• Differentiation of CD8+ T Cells Into Cytotoxic T Lymphocytes
• Effector Functions of CD8+ Cytotoxic T Lymphocytes
• Cytokine Production by CD8+ Effector T Cells
• Roles of CD8+ Cytotoxic T Lymphocytes in Host Defense
• Summary
• Chapter 12. B Cell Activation and Antibody Production
• Overview of Humoral Immune Responses
• Antigen Recognition and Antigen-Induced B Cell Activation
• Helper T Cell–Dependent Antibody Responses to Protein Antigens
• Antibody Responses to T-Independent Antigens
• Antibody Feedback: Regulation of Humoral Immune Responses By Fc Receptors
• Summary
• Chapter 13. Effector Mechanisms of Humoral Immunity
• Overview of Humoral Immunity
• Neutralization of Microbes and Microbial Toxins
• Antibody-Mediated Opsonization and Phagocytosis
• The Complement System
• Summary
• Chapter 14. Specialized Immunity at Epithelial Barriers and in Immune Privileged Tissues
• General Features of Immunity at Epithelial Barriers
• Immunity in the Gastrointestinal System
• Immunity in Other Mucosal Tissues
• The Cutaneous Immune System
• Immune-Privileged Tissues
• Immunity in the Mammalian Fetus and Newborn
• Summary
• Chapter 15. Immunologic Tolerance and Autoimmunity
• Overview of Immunologic Tolerance
• T Lymphocyte Tolerance
• B Lymphocyte Tolerance
• Tolerance to Commensal Microbes and Other Foreign Antigens
• Mechanisms of Autoimmunity
• Summary
• Chapter 16. Immunity to Microbes
• Overview of Immune Responses to Microbes
• Immunity to Extracellular Bacteria
• Immunity to Intracellular Bacteria
• Immunity to Fungi
• Immunity to Viruses
• Immunity to Parasites
• Strategies for Vaccine Development
• Summary
• Chapter 17. Transplantation Immunology
• General Principles of Transplantation Immunology
• Immune Responses to Allografts
• Patterns and Mechanisms of Allograft Rejection
• Prevention and Treatment of Allograft Rejection
• Xenogeneic Transplantation
• Blood Transfusion and the Abo and Rh Blood Group Antigens
• Hematopoietic Stem Cell (HSC) Transplantation
• Summary
• Chapter 18. Tumor Immunology
• Overview of Tumor Immunity
• Tumor Antigens
• Immune Responses To Tumors
• Evasion of Immune Responses by Tumors
• Immunotherapy For Tumors
• Summary
• Chapter 19. Hypersensitivity Disorders
• Causes of Hypersensitivity Diseases
• Mechanisms and Classification of Hypersensitivity Reactions
• Diseases Caused by Antibodies and Antigen-Antibody Complexes
• Diseases Caused by T Lymphocytes
• Therapeutic Approaches for Immunologic Diseases
• Selected Immunologic Diseases: Pathogenesis and Therapeutic Strategies
• Summary
• Chapter 20. Allergy
• Overview of IgE-Dependent Allergic Reactions
• Production of IgE
• Cells Involved in Allergic Reactions
• Reactions Dependent on IgE and Mast Cells
• Genetic Susceptibility to Allergic Disease
• Allergic Diseases in Humans: Pathogenesis and Therapy
• The Protective Roles of Immune Reactions Mediated by IgE and Mast Cells
• Summary
• Chapter 21. Primary and Acquired Immunodeficiencies
• Overview of Immunodeficiency Diseases
• Primary (Congenital) Immunodeficiencies
• Secondary (Acquired) Immunodeficiencies
• Human Immunodeficiency Virus and Acquired Immunodeficiency Syndrome
• Summary
• Glossary
• Appendix I. Principal Features of Selected CD Molecules
• Appendix II. Cytokines
• Appendix III. Laboratory Techniques Commonly Used in Immunology
• Index