Efnisyfirlit

• Cover
• Title Page
• Copyright Page
• Dedication
• About the Author
• Preface
• Contents
• 1 Safety Practices and Quality in the Hematology Laboratory
• An Overview of the Hematology Laboratory
• Patient Safety
• Safety in the Hematology Laboratory
• Safe Work Practices and Protective Techniques for Infection Control
• Quality Assessment in the Hematology Laboratory
• Quality Control in the Hematology Laboratory
• Chapter Highlights
• Review Questions
• References
• Bibliography
• 2 Principles of Blood Collection
• Quality in Blood Collection
• Safe Blood Collection Equipment
• Safe Blood Collection Equipment
• Chapter Highlights
• Review Questions
• Case Studies
• References
• Bibliography
• Internet Sites
• 3 Cellular Morphology and Foundations of Genetic Hematopoietic Disorders
• Cellular Ultrastructure and Organization
• Cellular Membranes
• Cytoplasmic Organelles and Metabolites
• Apoptosis
• Chapter Highlights
• Review Questions
• Bibliography
• 4 Hematopoiesis
• Ontogeny of Hematopoiesis
• Hematopoietic Organs and Tissues
• Secondary Lymphoid Tissues
• Cellular Elements of Bone Marrow
• Human Stem Cells
• Cytokines
• Examination of Maturing Blood Cells
• Mature Blood Cells in Peripheral Blood
• Chapter Highlights
• Review Questions
• Bibliography
• 5 Erythrocytes: Erythropoiesis, Maturation, Membrane Characteristics, and Metabolic Activities
• Erythropoiesis
• Disorders Related to Erythrocyte Maturation and Production
• Membrane Characteristics and Metabolic Activities of Erythrocytes
• Chapter Highlights
• Case Study
• Review Questions
• Bibliography
• 6 Erythrocytes: Hemoglobin
• Characteristics of Hemoglobin
• Hemoglobin Function
• Oxygen Dissociation and Alterations
• Carbon Dioxide Transport
• Biosynthesis of Hemoglobin
• Disorders Related to Hemoglobin Biosynthesis
• Ontogeny of Hemoglobin
• Variant Forms of Normal Hemoglobin
• Abnormal Hemoglobin Molecules
• Analysis of Hemoglobin
• Catabolism of Erythrocytes
• Chapter Highlights
• Case Studies
• Review Questions
• Bibliography
• 7 Erythrocytes: Morphology and Inclusions
• Erythrocytes: Normal and Abnormal
• Types of Variations in Erythrocyte Size
• Kinds of Variations in Erythrocyte Shape
• Alterations in Erythrocyte Color
• Varieties of Erythrocyte Inclusions
• Alterations in Erythrocyte Distribution
• Parasitic Inclusions in Erythrocytes
• Chapter Highlights
• Case Studies
• Review Questions
• Bibliography
• 8 Leukocytes: The Granulocytic and Monocytic Series
• Introduction
• Granulocytic Series: Production of Neutrophils, Eosinophils, and Basophils
• Granulocyte Sites of Development and Maturation
• Distribution of Neutrophils, Eosinophils, and Basophils
• Normal Maturational Characteristics of Granulocytes
• Leukocyte Surface Markers
• The Monocytic-Macrophage Series
• Normal Reference Ranges and Variations
• Abnormalities in Granulocytic Reference Ranges
• Functional Properties of Monocytes/Macrophages
• Phagocytosis
• Chapter Highlights
• Case Study
• Review Questions
• Bibliography
• 9 Leukocytes: Lymphocytes and Plasma Cells
• Anatomical Origin and Development of Lymphocytes
• Morphological Characteristics of Normal Lymphocytes
• Characteristics of Lymphocytes
• T Lymphocytes, B Lymphocytes, and Plasma Cell Kinetics
• Plasma Cell Development and Maturation
• Chapter Highlights
• Review Questions
• Bibliography
• 10 Basic Laboratory Assessment of Erythrocytes, Leukocytes, and Platelets
• The Complete Blood Count
• Quantitative Assessment of Erythrocytes
• Quantitative Assessment of Leukocytes
• Other Leukocyte-Related Assessments
• Quantitative Assessment of Platelets
• Peripheral Blood Film Evaluation
• Semiquantitative Grading of Erythrocyte Morphology
• Semiquantitative Assessment of Leukocytes
• Semiquantitative Assessment of Platelets
• Leukocyte Differential Count
• Chapter Highlights
• Review Questions
• Bibliography
• 11 Classification and Laboratory Assessment of Anemias
• Overview of Anemia
• Development of Anemia
• Clinical Signs and Symptoms of Anemia
• Classification of Anemias
• Laboratory Assessment of Anemias
• Chapter Highlights
• Review Questions
• Bibliography
• 12 Acute and Chronic Blood Loss Anemia and Anemias Associated with Systemic Disorders
• Acute Blood Loss Anemia
• Chronic Blood Loss Anemia
• Chapter Highlights
• Case Studies
• Review Questions
• Bibliography
• 13 Bone Marrow Failure Syndromes
• Bone Marrow Failure Syndromes
• Acquired Aplastic Anemia
• Constitutional Bone Marrow Failure Syndromes Associated with Aplastic Anemia
• Bone Marrow Failures Involving a Single-Cell Lineage
• Congenital Amegakaryocytic Thrombocytopenia
• Chapter Highlights
• Case Studies
• Review Questions
• Bibliography
• 14 Disorders of Iron Metabolism and Heme Synthesis
• Iron Deficiency and Iron Overload
• Iron Deficiency and Iron Deficiency Anemia
• Iron Deficiency Anemia
• Anemia of Inflammation or Anemia of Chronic Disorders/Diseases
• Disorders Related to Hemoglobin Biosynthesis: Sideroblastic Anemia
• Disorders Related to Hemoglobin Biosynthesis: Hereditary Hemochromatosis
• Disorders Related to Hemoglobin Biosynthesis: Heme (Porphyrin) Synthesis
• Disorders Related to Hemoglobin Biosynthesis: Disorders of Globulin Synthesis
• Chapter Highlights
• Case Studies
• Review Questions
• Bibliography
• 15 Macrocytic and Megaloblastic Anemias
• Macrocytic Anemias
• Megaloblastic Anemias
• Pernicious Anemia
• Folic Acid Deficiency Anemia
• Chapter Highlights
• Case Study
• Review Questions
• Bibliography
• 16 Hemolytic Anemias
• Hemolytic Anemias
• The Role of Complement in Hemolytic Anemia
• Complement-Mediated Disease
• Chapter Highlights
• Case Studies
• Review Questions
• Bibliography
• 17 Hemoglobinopathies and Thalassemias
• Hemoglobin Defects
• Sickle Cell Disease
• Sickle Cell Syndromes: Pathogenesis and New Approaches
• Thalassemia
• Other Hemoglobinopathies
• Hereditary Persistence of Fetal Hemoglobin
• Chapter Highlights
• Case Studies
• Review Questions
• Bibliography
• 18 Disorders of Granulocytes and Monocytes
• Granulopoietic Alterations: Quantitative Disorders
• Morphological Abnormalities of Mature Granulocytes
• Inherited Functional Abnormalities
• Granulopoietic Alterations: Qualitative Disorders
• Monocyte-Macrophage Disorders
• Chapter Highlights
• Case Studies
• Review Questions
• Bibliography
• 19 Disorders of Lymphocytes
• Characteristics of Lymphocytes
• Lymphocytosis
• Disorders Associated with Lymphocytosis
• Lymphocytopenia
• Immune Disorders Associated with Lymphocytopenia
• Chapter Highlights
• Case Studies
• Review Questions
• Bibliography
• 20 Characteristics of Leukemias, Lymphomas, and Myelomas
• Comparison of Leukemias, Lymphomas, and Myelomas
• Forms of Leukemia
• Classifications of Leukemias
• Prognosis and Treatment
• Factors Related to the Occurrence of Leukemia
• Demographic Distribution of Leukemia and Lymphomas
• Leukemia Vaccines
• Chapter Highlights
• Review Questions
• Bibliography
• 21 Acute Leukemias
• General Characteristics of Acute Leukemias
• Acute Myeloid Leukemias
• Prognosis of AML
• Treatment Options
• Acute Lymphoblastic Leukemia
• Prognosis of ALL
• Life-Threatening Emergencies
• Future Trends: Vaccines
• Chapter Highlights
• Case Studies
• Review Questions
• Bibliography
• 22 Lymphoid and Plasma Cell Neoplasms
• Leukemias versus Lymphomas
• Chronic Lymphocytosis
• T-Cell and NK-Cell Neoplasms
• Lymphomas
• Hodgkin Disease
• Plasma Cell Dyscrasias
• Immune Approaches
• Waldenström Primary Macroglobulinemia (Lymphoplasmacytic Lymphoma)
• Chapter Highlights
• Case Studies
• Review Questions
• Bibliography
• 23 Myeloproliferative Neoplasms
• General Characteristics of Myeloproliferative Neoplasms
• Chronic Myelogenous Leukemia
• Polycythemia Vera, Essential Thrombocytosis (Essential Thrombocythemia), and Primary Myelofibrosis
• Polycythemia Vera
• Primary Myelofibrosis
• Essential Thrombocytosis/Essential Thrombocythemia
• Mastocytosis
• Myeloproliferative Neoplasm, Unclassifiable (MPN-U)
• Chapter Highlights
• Case Studies
• Review Questions
• Bibliography
• 24 Myelodysplastic Syndromes and Myelodysplastic/Myeloproliferative Neoplasms
• General Characteristics of Myelodysplastic Syndrome and Myelodysplastic/Myeloproliferative Neoplasms
• Myelodysplastic Syndromes
• Relationship of Cytogenetics to Prognosis
• Treatment Strategies
• Myelodysplastic Syndromes/Myeloproliferative Neoplasms (MDS/MPN)
• Chapter Highlights
• Case Studies
• Review Questions
• Bibliography
• 25 Principles of Hemostasis and Thrombosis: Vasculature and Platelets
• Overview of Hemostasis and Thrombosis
• Blood Vasculature: Structure and Function
• Vasculature Physiology
• Thrombopoiesis
• Cell-Based Mechanism of Hemostasis: Platelet Function
• Chapter Highlights
• Review Questions
• Bibliography
• 26 Disorders of Primary Hemostasis and Thrombosis Vasculature and Platelets
• Vascular Abnormalities
• Quantitative Platelet Disorders
• Qualitative Characteristics of Platelets: Thrombocytopathy/Thrombocythemia
• Chapter Highlights
• Case Study
• Review Questions
• Bibliography
• 27 Principles of Hemostasis and Thrombosis: Blood Coagulation Factors and Natural Coagulant Systems
• Blood Coagulation Factors
• Normal Protective Mechanisms against Thrombosis
• Modern View of Hemostasis
• Chapter Highlights
• Review Questions
• Bibliography
• 28 Disorders of Hemostasis and Thrombosis: Blood Coagulation Factors, Hypercoagulable State, and Anticoagulant Therapy
• Introduction
• Defective Production
• Disorders of Destruction and Consumption
• The Hypercoagulable (Thrombophilia)
• Anticoagulant Therapy
• Chapter Highlights
• Case Studies
• Review Questions
• Bibliography
• 29 Body Fluid Analysis
• Introduction
• Cerebrospinal Fluid
• Pleural, Peritoneal, and Pericardial Fluids
• Chapter Highlights
• Case Studies
• Review Questions
• Bibliography
• 30 Instrumentation in Hematology
• Instrumental Principles
• Whole Blood Cell Analysis
• Analysis of Instrumental Data Output
• Laser Technology
• Applications of Flow Cytometry
• Digital Microscopy
• Instruments in Coagulation Studies
• Chapter Highlights
• Case Studies
• Review Questions
• Bibliography
• 31 Molecular Diagnostic Techniques and Applications
• The Human Genome Project
• Molecular Techniques in Hematology
• Molecular Genetics in Hematology
• Chapter Summary
• Review Questions
• Bibliography
• 32 Laboratory Manual: Manual Procedures in Hematology
• Procedural Format
• Review Questions
• A Answers to Review Questions
• B Frequently Used Abbreviations
• C Safety Data Sheets
• D Tube Guide BD
• E Tube Guide Greiner
• F Interleukins
• G The Microscope
• H Quick References
• Glossary
• Index