Efnisyfirlit

• Cover
• Title Page
• Copyright
• ABOUT THE COMPANION WEBSITE
• CHAPTER ONE: The Beginnings of Molecular Biology
• 1.1 Introduction
• 1.2 Insights into the nature of the hereditary material
• 1.3 A model for the structure of DNA: The DNA double helix
• 1.4 The central dogma of molecular biology
• 1.5 An evolutionary framework for heredity
• BIBLIOGRAPHY
• CHAPTER TWO: The Structure of DNA
• 2.1 Introduction
• 2.2 Primary structure: the components of nucleic acids
• 2.3 Secondary structure of DNA
• 2.4 Unusual DNA secondary structures
• 2.5 Tertiary structure of DNA
• BIBLIOGRAPHY
• CHAPTER THREE: The Versatility of RNA
• 3.1 Introduction
• 3.2 RNA is involved in a wide range of cellular processes
• 3.3 Structural motifs of RNA
• 3.4 The discovery of RNA catalysis
• 3.5 RNA‐based genomes
• BIBLIOGRAPHY
• CHAPTER FOUR: Protein Structure and Folding
• 4.1 Introduction
• 4.2 Primary structure: amino acids and the genetic code
• 4.3 The three‐dimensional structure of proteins
• 4.4 Protein function and regulation of activity
• 4.5 Protein folding and misfolding
• BIBLIOGRAPHY
• CHAPTER FIVE: Genome Organization and Evolution
• 5.1 Introduction
• 5.2 Genome organization varies in different organisms
• 5.3 Packaging of the eukaryotic genome
• 5.4 The majority of the eukaryotic genome is noncoding
• 5.5 Lateral gene transfer contributes to genome evolution
• 5.6 Prokaryotic and viral genome organization
• BIBLIOGRAPHY
• CHAPTER SIX: DNA Replication and Telomere Maintenance
• 6.1 Introduction
• 6.2 Early insights into the mode of bacterial DNA replication
• 6.3 DNA polymerases are the enzymes that catalyze DNA synthesis from 5′ to 3′
• 6.4 The bacterial replisome
• 6.5 The eukaryotic replisome
• 6.6 Alternative modes of circular DNA replication
• 6.7 Telomere maintenance: the role of telomerase in DNA replication, aging, and cancer
• BIBLIOGRAPHY
• CHAPTER SEVEN: DNA Repair Pathways
• 7.1 Introduction
• 7.2 Mutations and DNA damage
• 7.3 Lesion bypass
• 7.4 Direct reversal of DNA damage
• 7.5 Repair of single base changes and structural distortions by removal of DNA damage
• 7.6 Double‐strand break repair by removal of DNA damage
• BIBLIOGRAPHY
• CHAPTER EIGHT: Transcription in Bacteria
• 8.1 Introduction
• 8.2 Mechanism of transcription
• 8.3 Insights into gene regulation from the lactose (lac) operon
• 8.4 Mode of action of transcriptional regulators
• 8.5 Control of gene expression by RNA
• 8.6 Gene regulatory networks
• BIBLIOGRAPHY
• CHAPTER NINE: Transcription in Eukaryotes
• 9.1 Introduction
• 9.2 Overview of transcriptional regulation
• 9.3 Protein‐coding gene regulatory elements
• 9.4 The general transcription machinery and mechanism of transcription
• 9.5 The role of specific transcription factors in gene regulation
• 9.6 Transcriptional coactivators and corepressors
• 9.7 Transcription complex assembly: the enhanceosome model versus the “hit‐and‐run” model
• 9.8 Regulated nuclear import and export of transcription factors
• BIBLIOGRAPHY
• CHAPTER TEN: Epigenetic Mechanisms of Gene Regulation
• 10.1 Introduction
• 10.2 Epigenetic markers
• 10.3 Genomic imprinting
• 10.4 X chromosome inactivation
• 10.5 Epigenetic control of transposable elements
• 10.6 Epigenetics and nutritional legacy
• 10.7 Allelic exclusion
• BIBLIOGRAPHY
• CHAPTER ELEVEN: RNA Processing and Posttranscriptional Gene Regulation
• 11.1 Introduction
• 11.2 The discovery of split genes
• 11.3 Splicing occurs by a variety of mechanisms
• 11.4 Cotranscriptional processing of nuclear pre‐mRNA
• 11.5 Alternative splicing
• 11.6 RNA editing
• 11.7 Post‐transcriptional gene regulation by RNAi
• 11.8 RNA turnover in the nucleus and cytoplasm
• BIBLIOGRAPHY
• CHAPTER TWELVE: The Mechanism of Translation
• 12.1 Introduction
• 12.2 Ribosome structure and assembly
• 12.3 Aminoacyl‐tRNA synthetases
• 12.4 Initiation of translation
• 12.5 Elongation and events in the ribosome tunnel
• 12.6 Termination of translation
• 12.7 Translational and post‐translational control
• BIBLIOGRAPHY
• CHAPTER THIRTEEN: Recombinant DNA Technology and Genetically Modified Organisms
• 13.1 Introduction
• 13.2 The beginnings of recombinant DNA technology
• 13.3 Cutting and joining DNA
• 13.4 Molecular cloning
• 13.5 Library screening and probes
• 13.6 Restriction mapping and RFLP analysis
• 13.7 DNA sequencing
• 13.8 Introduction to genetically modified organisms
• 13.9 Transgenic mice: pronuclear microinjection
• 13.10 Gene targeting in mouse embryonic stem cells
• 13.11 CRISPR‐Cas gene editing
• 13.12 Applications of genetically modified animals
• 13.13 Cloning by nuclear transfer
• 13.14 Transgenic plants
• BIBLIOGRAPHY
• CHAPTER FOURTEEN: Tools for Analyzing Gene Organization, Expression, and Function
• 14.1 Introduction
• 14.2 DNA typing
• 14.3 Genomics, proteomics, and beyond
• 14.4 Whole‐genome sequencing
• 14.5 Reporter genes
• 14.6 Transcriptomics: RNA expression and localization
• 14.7 Proteomics: protein expression and localization
• 14.8 Analysis of nucleic acid–protein interactions
• 14.9 Analysis of protein–protein interactions
• 14.10 Structural analysis of proteins
• BIBLIOGRAPHY
• CHAPTER FIFTEEN: Medical Molecular Biology
• 15.1 Introduction
• 15.2 Genomic medicine
• 15.3 Molecular biology of cancer
• 15.4 Gene therapy
• BIBLIOGRAPHY
• APPENDIX
• Chapter 1
• Chapter 2
• Chapter 3
• Chapter 4
• Chapter 5
• Chapter 6
• Chapter 7
• Chapter 8
• Chapter 9
• Chapter 10
• Chapter 11
• Chapter 12
• Chapter 13
• Chapter 14
• Chapter 15
• GLOSSARY
• Index
• End User License Agreement