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• Cover
• Introduction
• About This Book
• Conventions Used in This Book
• Foolish Assumptions
• How This Book Is Organized
• Icons Used in This Book
• Beyond This Book
• Where to Go from Here
• Part 1: The Lowdown on Genetics: Just the Basics
• Chapter 1: Welcome to Genetics: What’s What and Who’s Who
• What Is Genetics?
• Genetics as a Career
• Chapter 2: Basic Cell Biology
• Looking Around Your Cell
• Mitosis: Splitting Up
• Meiosis: Making Cells for Reproduction
• Chapter 3: Visualize Peas: Discovering the Laws of Inheritance
• Gardening with Gregor Mendel
• Speaking the Language of Inheritance
• Simplifying Inheritance
• Finding Unknown Alleles
• Applying Basic Probability to the Likelihood of Inheritance
• Solving Simple Genetics Problems
• Chapter 4: Law Enforcement: Mendel’s Laws Applied to Complex Traits
• Dominant Alleles Rule … Sometimes
• Alleles Causing Complications
• Making Life More Complicated
• Uncovering More Exceptions to Mendel’s Laws
• Part 2: DNA: The Genetic Material
• Chapter 5: DNA: The Basis of Life
• Chemical Ingredients of DNA
• Examining Different Varieties of DNA
• Digging into the History of DNA
• Chapter 6: Chromosomes: The Big Picture
• Deconstructing the Double Helix
• Anatomy of a Chromosome
• Two Chromosomes Are Better than One (or Three)
• Sex Chromosomes: Is It a Boy or Girl?
• Chapter 7: Replication: A Copy Machine for DNA
• Unzipped: Creating the Pattern for More DNA
• How DNA Copies Itself
• Replication in Eukaryotes
• How Circular DNAs Replicate
• Chapter 8: DNA Sequencing: Decoding the Genome
• Sequencing: Reading the Language of DNA
• Sequencing Your Way to the Human Genome
• Trying on a Few Genomes
• Chapter 9: RNA: DNA’s Close Cousin
• You Already Know a Lot about RNA
• Transcription: Copying DNA’s Message into RNA’s Language
• Post-transcription Processing
• Chapter 10: Translating the Genetic Code
• Discovering the Good in a Degenerate
• Meeting the Translating Team
• Taking the Translation Trip
• Proteins Are Precious Polypeptides
• Chapter 11: Gene Expression: What a Cute Pair of Genes
• Getting Your Genes Under Control
• To Be Expressed or Not To Be Expressed?
• Regulating Gene Expression: A Time and Place for Everything
• Controlling Transcription Before It Starts
• Regulation of Gene Transcription: Flipping the Switch
• Retroactive Control: Things That Happen after Transcription
• Gene Control Lost in Translation
• Prokaryotic Gene Expression
• Part 3: Genetics and Your Health
• Chapter 12: When Things Go Wrong: Changes in DNA Sequence
• Heritable or Not Heritable?
• Facing the Consequences of Sequence Variants
• Sorting Out Terminology
• What Causes Sequence Variants?
• Evaluating Options for DNA Repair
• Chapter 13: Chromosome Disorders: It’s All a Numbers Game
• Chromosome Numbers: No More and No Less
• Aneuploidy of the Autosomal Chromosomes
• Aneuploidy of the Sex Chromosomes
• Exploring Variations in Chromosome Structure
• How Chromosomes Are Studied
• Non-Invasive Prenatal Testing for Aneuploidy
• Chapter 14: Taking a Closer Look at the Genetics of Cancer
• Defining Cancer
• Recognizing Cancer as a DNA Disease
• Breaking Down the Types of Cancers
• Chapter 15: Genetic Counseling, Risk Assessment, and Genetic Testing
• Getting to Know Genetic Counselors
• Building and Analyzing a Family Tree
• Autosomal Inheritance: No Differences Among the Sexes
• Found on Sex Chromosomes: Sex-linked Inheritance
• Testing for Genetic Disorders
• Chapter 16: Treating Genetic Disorders and Using Genetics to Tailor Treatment
• Alleviating Genetic Disease through Gene Therapy
• Inserting Healthy Genes into the Picture
• Finding Vehicles to Get Genes to Work
• Progress on the Gene Therapy Front
• Utilizing Genetic Information for Precision Medicine
• Part 4: Genetics and Your World
• Chapter 17: Tracing Human History and the Future of the Planet
• Genetic Variation Is Everywhere
• Breaking Down the Hardy-Weinberg Law of Population Genetics
• Mapping the Gene Pool
• Changing Forms over Time: The Genetics of Evolution
• Chapter 18: Solving Mysteries Using DNA
• Rooting through Your DNA to Find Your Identity
• Investigating the Scene: Where’s the DNA?
• Employing DNA to Catch Criminals (And Free the Innocent)
• It’s All Relative: Finding Family
• Chapter 19: Genetic Makeovers: Using Genetic Engineering to Change the Genome
• Genetically Modified Organisms Are Everywhere
• Old Genes in New Places
• Looking at the GMO Menagerie
• Transgenic plants
• Changing the Blueprint: Gene Editing
• Chapter 20: Giving Ethical Considerations Their Due
• Profiling Genetic Discrimination
• Ordering Up Designer Babies
• Ethical Issues Surrounding Genetic Testing
• Informed Consent
• Patient Autonomy
• Privacy and Confidentiality
• Incidental Findings
• Direct-to-Consumer Testing
• Practicing Safe Genetic Treatments
• Genetic Property Rights
• Part 5: The Part of Tens
• Chapter 21: Ten Defining Events in Genetics
• The Publication of Darwin’s “The Origin of Species”
• The Rediscovery of Mendel’s Work
• DNA Transformation
• The Discovery of Jumping Genes
• The Birth of DNA Sequencing
• The Invention of PCR
• The Development of Recombinant DNA Technology
• The Invention of DNA Fingerprinting
• The Birth of Developmental Genetics
• The Work of Francis Collins and the Human Genome Project
• Chapter 22: Ten Hot Issues in Genetics
• Direct-to-Consumer Genetic Testing
• Whole Exome Sequencing
• Whole Genome Sequencing
• Stem Cell Research
• The ENCODE Project
• Proteomics
• Gene Chips
• Evolution of Antibiotic Resistance
• Circumventing Mother Nature
• Genetics from Afar
• Glossary
• Index
• About the Authors
• Connect with Dummies
• End User License Agreement