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• Cover
• Dedication Page
• Title Page
• Copyright Page
• Acknowledgments
• How to Use This Book
• About the Companion Website
• LECTURE 1: An Overview
• INTRODUCTION
• PHYSICAL BARRIERS
• THE INNATE IMMUNE SYSTEM
• THE ADAPTIVE IMMUNE SYSTEM
• A COMPARISON OF THE INNATE AND ADAPTIVE IMMUNE SYSTEMS
• THE INNATE SYSTEM RULES!
• EPILOGUE
• LECTURE 2: The Innate Immune System
• INTRODUCTION
• THE COMPLEMENT SYSTEM
• THE PROFESSIONAL PHAGOCYTES
• HOW IMMUNE SYSTEM SENTINELS RECOGNIZE INVADERS
• HOW THE INNATE IMMUNE SYSTEM DEALS WITH VIRUSES
• THE INNATE IMMUNE SYSTEM – A COOPERATIVE EFFORT
• A PROPORTIONAL RESPONSE
• SUMMARY FIGURE
• LECTURE 3: B Cells and Antibodies
• INTRODUCTION
• THE B CELL RECEPTOR
• HOW THE BCR SIGNALS
• HOW B CELLS ARE ACTIVATED
• CLASS SWITCHING
• ANTIBODY CLASSES AND THEIR FUNCTIONS
• SOMATIC HYPERMUTATION
• B CELLS MAKE A CAREER CHOICE
• SUMMARY FIGURE
• LECTURE 4: The Magic of Antigen Presentation
• INTRODUCTION
• CLASS I MHC MOLECULES
• CLASS II MHC MOLECULES
• ANTIGEN PRESENTATION BY CLASS I MHC MOLECULES
• ANTIGEN PRESENTATION BY CLASS II MHC MOLECULES
• ANTIGEN PRESENTING CELLS
• THE LOGIC OF CLASS I MHC PRESENTATION
• THE LOGIC OF CLASS II MHC PRESENTATION
• CROSS‐PRESENTATION
• NON‐CLASSICAL MHC MOLECULES AND LIPID PRESENTATION
• MHC PROTEINS AND ORGAN TRANSPLANTS
• SUMMARY FIGURE
• LECTURE 5: T Cell Activation
• INTRODUCTION
• T CELL RECEPTORS
• HOW A T CELL’S RECEPTORS SIGNAL
• CD4 AND CD8 CO‐RECEPTORS
• CO‐STIMULATION
• A TIME‐LAPSE PHOTO OF HELPER T CELL ACTIVATION
• HOW KILLER T CELLS ARE ACTIVATED
• LECTURE 6: T Cells at Work
• INTRODUCTION
• HELPER T CELLS AS CYTOKINE FACTORIES
• THE DENDRITIC CELL AS “COACH” OF THE IMMUNE SYSTEM TEAM
• Th1 HELPER T CELLS
• Th2 HELPER T CELLS
• Th17 HELPER T CELLS
• Th0 HELPER T CELLS
• LOCKING IN THE HELPER T CELL PROFILE
• DELAYED‐TYPE HYPERSENSITIVITY
• HOW CTLs KILL
• SUMMARY FIGURE
• LECTURE 7: Secondary Lymphoid Organs and Lymphocyte Trafficking
• INTRODUCTION
• LYMPHOID FOLLICLES
• HIGH ENDOTHELIAL VENULES
• LYMPH NODES
• PEYER’S PATCHES
• THE SPLEEN
• THE LOGIC OF SECONDARY LYMPHOID ORGANS
• LYMPHOCYTE TRAFFICKING
• WHY MOTHERS KISS THEIR BABIES
• LECTURE 8: Restraining the Immune System
• INTRODUCTION
• ATTENUATING THE IMMUNE RESPONSE
• DEACTIVATING THE SYSTEM
• LIFE IS SHORT
• EXHAUSTION
• LECTURE 9: Self Tolerance and MHC Restriction
• INTRODUCTION
• THE THYMUS
• MHC RESTRICTION
• THE LOGIC OF MHC RESTRICTION
• THYMIC TESTING FOR TOLERANCE OF SELF
• GRADUATION
• THE RIDDLE OF MHC RESTRICTION AND TOLERANCE INDUCTION
• TOLERANCE BY IGNORANCE
• TOLERANCE INDUCTION IN SECONDARY LYMPHOID ORGANS
• PERIPHERAL TOLERANCE INDUCTION
• TOLERANCE DUE TO ACTIVATION‐INDUCED CELL DEATH
• B CELL TOLERANCE
• MAINTENANCE OF B CELL TOLERANCE IN GERMINAL CENTERS
• THE EDUCATION OF NATURAL KILLER CELLS
• LECTURE 10: Immunological Memory
• INTRODUCTION
• INNATE MEMORY
• ADAPTIVE MEMORY
• PROPERTIES OF ADAPTIVE MEMORY CELLS
• COMPARING B AND T CELL MEMORIES
• INNATE VERSUS ADAPTIVE MEMORY
• LECTURE 11: The Intestinal Immune System
• INTRODUCTION
• INTESTINAL ARCHITECTURE
• CHALLENGES FACED BY THE INTESTINAL IMMUNE SYSTEM
• RESPONDING GENTLY TO LIMITED THREATS
• THE INTESTINAL IMMUNE SYSTEM’S RESPONSE TO PATHOGENS
• HOW TO RESPOND?
• LECTURE 12: The Immune System Gone Wrong
• INTRODUCTION
• DISEASES CAUSED BY DEFECTS IN IMMUNE REGULATION
• AUTOIMMUNE DISEASE
• LECTURE 13: Immunodeficiency
• INTRODUCTION
• GENETIC DEFECTS LEADING TO IMMUNODEFICIENCY
• AIDS
• LECTURE 14: Vaccines
• INTRODUCTION
• GENERATING MEMORY HELPER T AND B CELLS
• GENERATING MEMORY KILLER T CELLS
• STRATEGIES FOR VACCINE DEVELOPMENT
• WILL THERE BE AN AIDS VACCINE?
• VACCINATION TO PREVENT VIRUS‐ASSOCIATED CANCER
• VACCINE ADJUVANTS
• LECTURE 15: Cancer and the Immune System
• INTRODUCTION
• CANCER IS A CONTROL SYSTEM PROBLEM
• CLASSIFICATION OF CANCER CELLS
• IMMUNE SURVEILLANCE AGAINST CANCER
• IMMUNE SURVEILLANCE BY MACROPHAGES AND NK CELLS
• LECTURE 16: Immunotherapy
• INTRODUCTION
• IMMUNOTHERAPY USING MONOCLONAL ANTIBODIES
• IMMUNOTHERAPY USING T CELLS
• LECTURE 17: COVID‐19 and the Immune System
• INTRODUCTION
• THE RESPIRATORY SYSTEM
• SARS‐CoV‐2
• THE IMMUNE RESPONSE TO RESPIRATORY VIRUSES
• THE PATHOLOGY OF A SARS‐CoV‐2 INFECTION
• THE mRNA VACCINE PLATFORM
• mRNA VACCINATION VERSUS NATURAL INFECTION
• CORRELATES OF PROTECTION
• REINFECTION
• VIRAL VARIANTS
• Glossary
• Acronyms and Abbreviations
• Index
• End User License Agreement