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• Cover
• Companion Website
• Title
• Copyright
• Preface
• Acknowledgements
• Note on the Tenth Edition
• How to Use This Book
• Further Reading
• List of Abbreviations
• 1 The Scope of Immunology
• 2 Innate and Adaptive Immune Mechanisms
• Innate Immunity
• Adaptive Immunity
• Interactions between Innate and Adaptive Immunity
• 3 Recognition and Receptors: The Keys to Immunity
• Innate Immune System
• Cell-Associated Recognition
• Some Other Receptor Systems
• Adaptive Immune System
• 4 Cells Involved in Immunity: The Haemopoietic System
• A Note on Terminology
• 5 Receptors of the Innate Immune System
• 6 Complement
• Classic Pathway
• Alternative Pathway
• MBL and Other Pathways
• Lytic Pathway
• Complement Inhibitors
• 7 Acute Inflammation
• 8 Phagocytic Cells and the Reticuloendothelial System
• 9 Phagocytosis
• 10 Evolution of Recognition Molecules: The Immunoglobulin Superfamily
• 11 The Major Histocompatibility Complex
• 12 The T-Cell Receptor
• 13 Antibody Diversification and Synthesis
• 14 Antibody Structure and Function
• 15 Lymphocytes
• 16 Primary Lymphoid Organs and Lymphopoiesis
• Yolk Sac
• Bursa
• Liver
• Bone Marrow
• Thymus
• 17 Secondary Lymphoid Organs and Lymphocyte Traffic
• Lymph Node
• Spleen
• Mucosa-Associated Lymphoid Tissues
• 18 Antigen processing and presentation
• The Class I Pathway
• The Class II Pathway
• 19 The Antibody Response
• 20 Antigen – Antibody Interaction and Immune Complexes
• Antigen – Antibody Interaction
• Immune Complexes
• 21 Cell-Mediated Immune Responses
• 22 Tolerance
• 23 Cell Communication and Cytokines
• 24 The Cytokine Network
• 25 Immunity, Hormones and the Brain
• Central Nervous System
• Autonomic Nervous System
• Endocrine System
• Immune System
• Immunity and Psychological Illness
• 26 Antimicrobial Immunity: a General Scheme
• 27 Immunity to Viruses
• Viruses
• Atypical Organisms
• 28 HIV and AIDS
• 29 Immunity to Bacteria
• Bacteria
• 30 Immunity to Fungi and Ectoparasites
• Ectoparasites
• 31 Immunity to Protozoa
• 32 Immunity to Worms
• Roundworms (Nematodes)
• Flukes (Trematodes)
• Tapeworms (Cestodes)
• 33 Immunodeficiency
• Defects Affecting Several Types of Cell
• Defects Predominantly Affecting T Cells
• Defects Predominantly Affecting B Cells
• Defects of Complement
• Defects Affecting Myeloid Cells
• Receptors of Innate Immunity
• Secondary Immunodeficiency
• 34 Harmful Immunity: a General Scheme
• Innate Immune Damage
• Types of Hypersensitivity (Gell and Coombs’ Classification)
• 35 Allergy and Anaphylaxis
• Mediators
• Inhibitors
• Non-IgE Triggering
• Allergic Diseases
• 36 Immune Complexes, Complement and Disease
• Immune Complex Diseases
• Haemolytic Disease of the Newborn
• 37 Chronic and cell-mediated inflammation
• Granulomas
• Granulomatous Diseases
• 38 Autoimmune Disease
• Self-Tolerance and Self-Reactivity
• Autoimmune Diseases
• Treatment of Autoimmunity
• 39 Transplant Rejection
• Typing and Matching
• Rejection
• Immunosuppression
• 40 Immunosuppression
• Non-specific Immunosuppression
• Specific Immunosuppression
• 41 Immunostimulation and Vaccination
• Passive Immunization
• Active Immunization (‘vaccination’)
• 42 Cancer Immunology
• Non-Specific Immunotherapy
• Specific Immunotherapy
• 43 Immunity and Clinical Medicine
• 44 Investigating Immunity
• Investigating Immunodeficiency
• Investigating Allergy
• Investigating Autoimmunity
• Tissue Typing and Transplantation
• Tumours of Immunological Cells
• 45 Immunology in the Laboratory
• 46 Out of the Past: Evolution of Immune Mechanisms
• Unicellular Organisms
• Invertebrates
• Vertebrates
• Plants
• 47 Into the future: immunology in the age of genomics
• Self-Assessment Questions
• Answers
• Appendix I: Comparative Sizes
• Comparative Molecular Weights
• Appendix II: Landmarks in the History of Immunology
• Some Unsolved Problems
• Appendix III: CD Classification
• Index
• End User License Agreement