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• Cover
• Title Page
• Publisher’s Notice
• Copyright
• Preface
• What’s New in the Tenth Edition
• Resources for Instructors and Students
• Acknowledgments
• About the Authors
• Contents in Brief
• Detailed Contents
• Chapter 1: Basic Concepts in Immunology
• The origins of vertebrate immune cells.
• Principles of innate immunity.
• Principles of adaptive immunity.
• The effector mechanisms of immunity.
• References
• Chapter 2: Innate Immunity: The First Lines of Defense
• Anatomic barriers and initial chemical defenses.
• The complement system and innate immunity.
• End of Chapter Questions and References
• Chapter 3: Cellular Mechanisms of Innate Immunity
• Pathogen recognition by cells of the innate immune system.
• Consequences of innate immune activation.
• End of Chapter Questions and References
• Chapter 4: Antigen Recognition by B-cell and T-cell Receptors
• The structure of a typical antibody molecule.
• Structural variation in immunoglobulin constant regions.
• The interaction of the antibody molecule with specific antigen.
• Antigen recognition by T cells.
• End of Chapter Questions and References
• Chapter 5: The Generation of Lymphocyte Antigen Receptors
• Primary immunoglobulin gene rearrangements and expression.
• T-cell receptor gene rearrangement.
• Evolution of the adaptive immune response.
• End of Chapter Questions and References
• Chapter 6: Antigen Presentation to T Lymphocytes
• The generation of αβ T-cell receptor ligands.
• The major histocompatibility complex and its function.
• Recognition of nonpeptide ligands by unconventional T-cell subsets.
• End of Chapter Questions and References
• Chapter 7: Lymphocyte Receptor Signaling
• General principles of signal transduction and propagation.
• Antigen receptor signaling and lymphocyte activation.
• Co-stimulatory and inhibitory receptors modulate antigen receptor signaling in T and B lymphocytes.
• End of Chapter Questions and References
• Chapter 8: The Development of B and T Lymphocytes
• Development of B lymphocytes.
• Development of T lymphocytes.
• Positive and negative selection of T cells.
• End of Chapter Questions and References
• Chapter 9: T Cell–Mediated Immunity
• Development and function of secondary lymphoid organs–sites for the initiation of adaptive immune responses.
• Naive T-cell activation, clonal expansion, and differentiation into effector and memory T cells.
• General properties of effector T cells and their cytokines.
• T cell–mediated cytotoxicity.
• End of Chapter Questions and References
• Chapter 10: The Humoral Immune Response
• B-cell activation by antigen and helper T cells.
• The distributions and functions of immunoglobulin classes.
• The destruction of antibody-coated pathogens via Fc receptors.
• End of Chapter Questions and References
• Chapter 11: Integrated Dynamics of Innate and Adaptive Immunity
• Integration of innate and adaptive immunity in response to specific types of pathogens.
• Effector CD4 T cells augment the effector functions of innate immune cells.
• Immunological memory.
• End of Chapter Questions and References
• Chapter 12: The Barrier Immune System
• Organization of the mucosal immune system.
• Innate immune defenses of the intestinal immune system.
• The role of adaptive immunity in regulating the intestinal mucosal immune system at homeostasis.
• The intestinal immune response in host defense and immune-mediated disease.
• Immunity at other barrier tissues.
• End of Chapter Questions and References
• Chapter 13: Failures of Host Defense Mechanisms
• Immunodeficiency diseases.
• Evasion and subversion of immune defenses.
• Acquired immune deficiency syndrome.
• End of Chapter Questions and References
• Chapter 14: Allergic Diseases and Hypersensitivity Reactions
• IgE and IgE-mediated allergic diseases.
• Effector mechanisms in IgE-mediated allergic reactions.
• Non-IgE-mediated allergic diseases.
• End of Chapter Questions and References
• Chapter 15: Autoimmunity and Transplantation
• The making and breaking of self-tolerance.
• Autoimmune diseases and pathogenic mechanisms.
• The genetic and environmental basis of autoimmunity.
• Responses to alloantigens and transplant rejection.
• End of Chapter Questions and References
• Chapter 16: Manipulation of the Immune Response
• Fighting infectious diseases with vaccination.
• Using the immune response to attack tumors.
• Treatment of unwanted immune responses.
• End of Chapter Questions and References
• Appendix I: The Immunologist’s Toolbox
• Appendix II: CD Antigens
• Appendix III: Cytokines and Their Receptors
• Appendix IV: Chemokines and Their Receptors
• Glossary
• Credits
• Index
• Movies and Animations
• Endpaper