Efnisyfirlit

• Instructions for online access
• Cover image
• Title page
• Table of Contents
• Copyright
• Foreword to the Tenth Edition
• Preface to the Tenth Edition
• Online Clinical Overviews
• Online Special Topics
• Online Clinical Cases
• List of Contributors
• International Advisory Board
• Acknowledgements for the Tenth Edition
• 1. Diagnosis: The art of being a doctor
• Core Skills and Knowledge
• Diagnosis in the Clinical Consultation
• The medical consultation
• Clinical diagnostic reasoning
• Communicating a diagnosis
• Diagnosis, artificial intelligence and the future of medicine
• 2. Human genetics
• Core Skills and Knowledge
• Clinical skills for genetic medicine
• Introduction
• Clinical genetics
• The cellular basis of genetics
• Genetic disorders
• Techniques for studying the genetic code
• Genomic medicine
• The genetic basis of cancer
• 3. Immunity
• Core Skills and Knowledge
• Introducing the tissues, cells and molecules of the immune system
• Innate immune system
• Adaptive immune system
• Cell migration
• HLA molecules and antigen presentation
• The immune system in concert
• Laboratory investigations of the immune system
• Clinical immunodeficiency
• Allergic disease (immediate hypersensitivity)
• Autoimmune disease
• Organ rejection in clinical transplantation
• Immune-based therapies
• 4. Evidence-based practice
• Core Skills and Knowledge
• Introduction
• Asking Answerable Questions
• Searching for the Evidence
• Appraising the Evidence
• Applying the Evidence
• Section 1: Asking Answerable Questions and Searching for the Evidence
• Section 2: Critical Appraisal
• Section 3: Interpreting Odds Ratios, Confidence Intervals and P-Values
• Section 4: Multiple Choice Questions
• 5. Ethical practice and clinical communication
• Core Skills and Knowledge
• Ethics and the law
• Communication in medicine
• 6. Malignant disease
• Core Skills and Knowledge
• Clinical skills for malignant disease
• Introduction
• The biology of cancer
• Aetiology and epidemiology
• Screening and investigations
• Principles of cancer treatment
• Acute oncology
• Common solid tumour treatment
• Lung cancer
• Breast cancer
• Upper gastrointestinal cancers
• Lower gastrointestinal cancers
• Hepatobiliary and pancreatic cancers
• Urological cancers
• Gynaecological cancers
• Brain tumours
• Head and neck cancer
• Metastatic cancer of unknown primary
• 7. Palliative care and symptom control
• Core Skills and Knowledge
• Introduction and General Aspects
• Symptom Control
• Palliative Care in Non-Malignant Disease
• Care of the Dying
• 8. Sepsis and the treatment of bacterial infection
• Core Skills and Knowledge
• clinical skills for infection and sepsis
• Introduction
• Pathophysiology
• recognition of sepsis
• Management of Sepsis
• Antimicrobial Stewardship
• Antibiotic Therapies
• 9. Water balance, fluids and electrolytes
• Core skills and knowledge
• Clinical skills for water balance, fluids and electrolytes
• Water and Electrolytes
• Disorders of sodium concentration
• Disorders of potassium concentration
• Disorders of magnesium concentration
• Disorders of phosphate concentration
• Acid–Base Disorders
• 10. Critical care medicine
• Core Skills and Knowledge
• Introduction
• Clinical approach to the critically ill patient
• Applied cardiorespiratory physiology
• Disturbances of acid–base balance
• Shock, sepsis and acute disturbances of haemodynamic function
• Respiratory failure
• Acute respiratory distress syndrome
• Acute Kidney injury
• Neurocritical care
• Outcomes
• 11. Surgery
• Core Skills and Knowledge
• Clinical skills for surgery
• Introduction
• The pathophysiology of surgery
• Management of the perioperative patient
• The patient journey in surgery
• Surgical Ethics, Consent and the Law
• 12. Prescribing, therapeutics and toxicology
• Core Skills and Knowledge
• Prescribing
• Why do patients need drugs?
• The choice of drug
• The dose
• Prescribing in special populations
• Monitoring drug therapy
• Adverse drug reactions
• Drug interactions
• Information sources
• Poisoning
• Clinical approach to the poisoned patient
• Principles of management of poisoning
• Specific poisons
• Poisons in the natural world: additional online content
• 13. Global health
• Core Skills and Knowledge
• Introduction
• Millennium and Sustainable Development Goals
• Global Burden of Disease
• Poverty
• Water and Sanitation
• Organizations and the global health agenda
• Education
• Maternal and Child Health
• Mental health
• Accidents and Trauma
• Conflict and Catastrophe
• Economics and Politics in Global Health
• Social Determinants of Health
• Human rights and the value of engagement in global health
• 14. Public health
• Core Skills and Knowledge
• Introduction
• Key Concepts in Public Health
• Pillars of Public Health
• 15. Geriatric medicine, frailty and multimorbidity
• Core Skills and Knowledge
• Introduction
• Ageing
• Investigations in Older Adults
• Taking a History
• Multimorbidity, Sarcopenia and Frailty
• Comprehensive Geriatric Assessment
• Advance Care Planning
• The Most Common Issues in Older People
• Ageing Well and Advantages of Ageing
• 16. Haematology
• Core Skills and Knowledge
• Clinical skills for haematology
• Examination
• Investigations
• Introduction
• The red cell
• Anaemia: an introduction
• Microcytic anaemia
• Normocytic anaemia
• Macrocytic anaemias
• Anaemia due to marrow failure (aplastic anaemia)
• Haemolytic anaemias: an introduction
• Inherited haemolytic anaemia
• Acquired haemolytic anaemia
• Polycythaemia
• The spleen
• Blood transfusion
• Blood groups
• Procedure for blood transfusion in hospitals
• Complications of blood transfusion
• Strategies for the avoidance of unnecessary transfusion
• Blood, blood components and blood products
• The white cell
• Haemostasis
• Vascular disorders
• Platelet disorders
• Inherited coagulation disorders
• Acquired coagulation disorders
• 17. Haematological oncology
• Core Skills and Knowledge
• Clinical skills for haematological oncology
• Introduction
• Leukaemias
• Myelodysplasia
• Clinical features
• Investigations
• Management
• MDS/MPN overlap syndromes
• Lymphomas
• Myeloma and other plasma cell disorders
• 18. Rheumatology
• Core Skills and Knowledge
• Clinical skills for rheumatology
• Approach to the patient
• Anatomy and physiology of the normal joint
• Investigation of rheumatic disease
• Clinical conditions in rheumatology
• Common regional musculoskeletal problems
• Chronic pain syndromes
• Analgesic and anti-inflammatory drugs for musculoskeletal problems
• Disorders of collagen
• Osteoarthritis
• Inflammatory Arthritis
• Rheumatoid arthritis
• Spondyloarthritis
• Infections of joints
• Autoimmune rheumatic diseases
• Systemic inflammatory vasculitis
• Arthritis in children
• Rheumatological problems seen in other diseases
• Miscellaneous arthropathies
• 19. Bone disease
• Core Skills and Knowledge
• Clinical skills for bone disease
• Anatomy and physiology of bone
• Investigation of bone and calcium disorders
• Osteoporosis
• Osteonecrosis
• Paget’s disease of bone
• Rickets and osteomalacia
• Bone infections
• Neoplastic disease of bone
• Scheuermann’s disease
• 20. Infectious disease
• Core Skills and Knowledge
• Core content
• Clinical skills for infectious disease
• Introduction
• Clinical approach to the patient with a suspected infection
• Epidemiology and prevention of infections
• Principles and mechanisms of infection
• Viral Infections
• Virus infections of the skin and mucous membranes
• Virus infections of the respiratory tract
• Systemic viral infections
• Virus infections of the nervous system
• Virus infections of the gastrointestinal tract
• Viral hepatitis
• Viruses and malignant disease
• Viral haemorrhagic fevers
• Antiviral drugs
• Transmissible Spongiform Encephalopathies (Prion Diseases)
• Bacterial Infections
• Bacterial infections of the skin and soft tissues
• Bacterial infections of the respiratory tract
• Bacterial infections of the gastrointestinal tract
• Bacterial infections of the cardiovascular system
• Bacterial infections of the nervous system
• Bacterial bone and joint infections
• Bacterial infections of the urinary tract
• Systemic/multisystem bacterial infections
• Bacterial infections seen in developing and tropical countries
• Antibiotic therapies
• Fungal Infections
• Systemic fungal infections
• Subcutaneous fungal infections
• Superficial fungal infections
• Antifungal drugs
• Protozoal Infections
• Blood and tissue protozoa
• Gastrointestinal protozoa
• Helminthic Infections
• Nematodes
• Trematodes
• Cestodes
• Arthropod Ectoparasites
• 21. Endocrinology
• Core Skills and Knowledge
• Clinical skills for endocrinology
• Introduction
• The pituitary gland and hypothalamus
• Hypothalamo–Pituitary–adrenal axis
• The thyroid axis
• Hypothalamo–pituitary–gonadal axis
• Growth and puberty
• The Thirst Axis
• Disorders of Calcium Metabolism
• Hypoglycaemia in the non-diabetic patient
• Other endocrine disorders
• 22. Dermatology
• Core Skills and Knowledge
• Clinical Skills for Dermatology
• Introduction
• Skin structure and function
• Investigation of Skin Disease
• Principles of Dermatological Therapy
• Erythroderma and Loss of Skin Function (‘Skin Failure’)
• Common rashes
• Skin Infections
• Human Immunodeficiency Virus and the Skin
• Skin Signs of Systemic Disease
• Photosensitivity
• Blistering and Bullous Skin Disease
• Skin Tumours
• Disorders of Pigmentation
• Nail Disorders
• Hair Disorders
• Birth Marks and Neonatal Rashes
• Drug Eruptions
• 23. Diabetes mellitus
• Core Skills and Knowledge
• Clinical skills for diabetes mellitus
• Introduction
• Physiology of insulin structure, secretion and action
• Classification of diabetes
• Clinical Approach to the Patient With Diabetes
• Prevention of Type 2 Diabetes
• Management of diabetes
• Diabetic metabolic emergencies
• Complications of diabetes
• Psychosocial Implications of Diabetes
• Diabetes in special situations
• Organization of diabetes care
• 24. Lipid and metabolic disorders
• Core Skills and Knowledge
• Introduction
• History
• Examination
• Investigations
• Disorders of lipid metabolism
• Inherited metabolic diseases
• 25. Liaison psychiatry
• Core Skills and Knowledge
• Introduction
• Clinical approach to the patient with a psychiatric disorder
• Classification of psychiatric disorders
• Aetiology of psychiatric disorders
• Psychiatric aspects of physical diseases
• Sick role and illness behaviour
• Functional somatic syndromes
• Somatoform disorders
• Dissociative/conversion disorders
• Sleep difficulties
• Mood (affective) disorders
• Suicide and self-harm
• Anxiety disorders
• Alcohol misuse and dependence
• Drug misuse and dependence
• Schizophrenia
• Organic mental disorders
• Eating disorders
• Sexual disorders
• Personality disorders
• Involuntary Detention
• Mental Capacity Act
• 26. Neurology
• Core Skills and Knowledge
• Clinical skills for neurology
• Introduction
• Clinical approach to the patient with neurological disease
• Functional neuroanatomy
• Cranial nerves
• Motor control systems
• Lower motor neurone lesions
• Sensory pathways and pain
• Bladder control and sexual dysfunction
• Investigation of neurological disease
• Unconsciousness and coma
• Stroke
• Intracranial haemorrhage
• Headache, migraine and facial pain
• Epilepsy and loss of consciousness
• Movement disorders
• Neuroinflammatory disorders
• Nervous system infection
• Hydrocephalus
• Traumatic brain injury
• Spinal cord disease
• Neurodegenerative diseases
• Congenital disorders
• Neurogenetic disorders
• Paraneoplastic syndromes
• Peripheral nerve disease
• Muscle diseases
• 27. Ear, nose and throat and eye disease
• Core Skills and Knowledge
• Introduction to ENT
• Clinical approach to the patient with an ENT complaint
• Disorders of the Ear
• Clinical Approach to the Patient With a Disorder of the Ear
• Common disorders of the ear
• Disorders of the Nose
• Clinical Approach to the Patient With a Disorder of the Nose
• Common disorders of the nose
• Disorders of the Throat
• Clinical Approach to the Patient With a Disorder of the Throat
• Common disorders of the throat
• Disorders of the Eye
• Applied Anatomy and Physiology
• Clinical Approach to the Patient With a Disorder of the Eye
• Common disorders of the eye
• 28. Respiratory disease
• Core Skills and Knowledge
• Clinical skills for respiratory medicine
• Function of the respiratory system
• Clinical Approach to the Patient with Respiratory Disease
• Diseases of the Upper Respiratory Tract
• Obstructive Respiratory Disease
• Smoking
• Respiratory Infection
• Pleural Disease
• Tumours of the Respiratory Tract
• Bronchiectasis
• Interstitial Lung Diseases
• Lung and Heart–Lung Transplantation
• Occupational Lung Disease
• Miscellaneous Respiratory Disorders
• Disorders of the Diaphragm
• Mediastinal Lesions
• 29. Venous thromboembolic disease
• Core Skills and Knowledge
• Introduction
• Pathogenesis of Thrombosis
• Definitions
• Epidemiology and Risk Factors
• Clinical Features
• Diagnosis
• Management
• Complications
• Investigation of newly diagnosed venous thrombosis
• Prevention
• Anticoagulant agents
• 30. Cardiology
• Core Skills and Knowledge
• Clinical skills for cardiology
• ECG interpretation
• Anatomy, physiology and embryology of the heart
• Clinical approach to the patient with heart disease
• Therapeutic procedures
• Cardiac arrhythmias
• Bradycardias and heart block
• Supraventricular tachycardias
• Ventricular tachyarrhythmias
• Heart failure
• Coronary artery disease
• Angina
• Acute coronary syndromes
• Valvular heart disease
• Aortic valve
• tricuspid valve
• Pulmonary valve
• Prosthetic valves
• Infective endocarditis
• Congenital heart disease
• Marfan’s syndrome
• Pulmonary heart disease
• Myocardial and endocardial disease
• Myocardial disease
• Pericardial disease
• Peripheral vascular disease
• Peripheral venous disease
• 31. Hypertension
• Core Skills and Knowledge
• Introduction
• Clinical Approach to the Patient with Hypertension
• Measurement of blood pressure
• Phenotypes of Hypertension
• Causes of raised blood pressure
• Thresholds and Targets In Hypertension
• Hypertensive Target Organ Damage
• Treatment
• Managing blood pressure in hospital
• 32. Gastroenterology
• Core Skills and Knowledge
• Clinical Skills for Gastroenterology
• INTRODUCTION
• Anatomy and physiology of the gastrointestinal tract
• Investigation of Gastrointestinal Disease
• Functional Gastrointestinal Disorders
• Mouth
• Salivary Glands
• Pharynx and Oesophagus
• Stomach and Duodenum
• Acute and Chronic Gastrointestinal Bleeding
• Small Intestine
• Inflammatory Bowel Disease
• Colon and Rectum
• The Acute Abdomen
• Peritoneum
• 33. Nutrition
• Core Skills and Knowledge
• Introduction
• Water and Electrolyte Balance
• Dietary Requirements
• Protein–Energy Malnutrition
• Vitamins
• Fat-soluble vitamins
• Water-soluble vitamins
• Dietary Antioxidants
• Homocysteine, cardiovascular disease and B vitamins
• Minerals
• Nutrition and Ageing
• Obesity
• Nutritional Support
• Food Allergy and Food Intolerance
• Alcohol
• 34. Liver disease
• Core Skills and Knowledge
• Clinical skills for liver disease
• Introduction
• Anatomy of the liver and biliary system
• Functions of the liver
• Investigations in the patient with liver disease
• Jaundice
• Hepatitis
• Acute hepatic failure
• Autoimmune hepatitis
• Drug-induced chronic hepatitis
• Chronic hepatitis of unknown cause
• Non-alcoholic fatty liver disease
• Cirrhosis
• Alcoholic liver disease
• Budd–chiari syndrome
• Hepatic sinusoidal obstruction syndrome
• Fibropolycystic diseases
• Liver abscess
• Other infections of the liver
• Liver disease in pregnancy
• Liver tumours
• Miscellaneous conditions of the liver
• Drugs and the liver
• 35. Biliary tract and pancreatic disease
• Core Skills and Knowledge
• Introduction
• Gall Bladder and Biliary System
• Biliary system
• Miscellaneous conditions of the biliary tract
• Pancreas
• Pancreatitis
• Pancreatic cancer
• Pancreatic neuroendocrine tumours
• Clinical syndromes
• Investigations
• Management
• 36. Kidney and urinary tract disease
• Core Skills and Knowledge
• Clinical Skills for Nephrology
• Examination
• Introduction
• Anatomy and Physiology of the Kidney and Urinary Tract
• Investigation of Renal and Urinary Tract Disease
• The Glomerulus and Glomerular Disease
• Kidney Involvement in Other Diseases
• Hypertension and the Kidney
• Other Vascular Disorders of the Kidney
• Renal Calculi and Nephrocalcinosis
• Urinary Tract Obstruction
• Drugs and the Kidney
• Urinary Tract Infection
• Tubulointerstitial Nephritis
• Acute Kidney Injury
• Chronic Kidney Disease
• Cystic Renal Disease
• Tumours of the Kidney and Genitourinary Tract
• Diseases of the Prostate Gland
• The Urinary Tract in the Elderly
• 37. Sexually transmitted infections and human immunodeficiency virus
• Core Skills and Knowledge
• Clinical skills for STI and HIV care
• Sexually transmitted infections
• Asymptomatic STI screening
• Investigation of STIs
• Management, prevention and control
• Specific infections
• Human immunodeficiency virus and acquired immunodeficiency syndrome
• Clinical features of untreated hiv infection
• Clinical approach to the patient with HIV
• Management of HIV-positive patients
• Specific conditions associated with HIV infection
• Prevention and control of HIV infection
• 38. Obstetric medicine
• Core Skills and Knowledge
• Clinical Skills for Obstetric Medicine
• Introduction
• Hypertensive Disorders
• Liver Disease
• Cardiac Disease
• Thromboembolic Disease
• Respiratory Disease
• Neurological Disease
• Endocrine Disease
• Renal Disease
• Skin Disorders
• RHEUMATIC DISEASE
• Prescribing in Pregnancy
• 39. Women’s health
• Core Skills and Knowledge
• Clinical skills for women’s health
• Introduction
• The life course approach
• Miscarriage
• Heavy Menstrual Bleeding
• Abortion/Termination of Pregnancy
• Urinary Incontinence
• Domestic abuse and violence
• Gynaecological cancers
• 40. Men’s health
• Core Skills and Knowledge
• Clinical Skills For Men’s Health
• Introduction
• Specific Diseases of Men
• Diseases of the prostate gland
• Diseases of the Penis
• Testicular and Spermatic Cord Disease
• Lack of Libido and Erectile Dysfunction
• Priapism
• The Ageing Male
• 41. Environmental medicine
• Core Skills and Knowledge
• Air pollution
• Heat Injury
• Cold injury
• High altitude
• Diving
• Drowning
• Ionizing radiation
• Electric shock
• Lightning strike
• Inhaled smoke
• Index
• Normal Values